Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade.
Publication
, Journal Article
Yang, Q; Tadros, HJ; Sun, B; Bidzimou, M-T; Ezekian, JE; Li, F; Ludwig, A; Wehrens, XHT; Landstrom, AP
Published in: JACC Basic Transl Sci
December 2023
Junctional ectopic tachycardia (JET) is a potentially fatal cardiac arrhythmia. Hcn4:shJph2 mice serve as a model of nodal arrhythmias driven by ryanodine type 2 receptor (RyR2)-mediated Ca2+ leak. EL20 is a small molecule that blocks RyR2 Ca2+ leak. In a novel in vivo model of JET, Hcn4:shJph2 mice demonstrated rapid conversion of JET to sinus rhythm with infusion of EL20. Primary atrioventricular nodal cells demonstrated increased Ca2+ transient oscillation frequency and increased RyR2-mediated stored Ca2+ leak which was normalized by EL20. EL20 was found to be rapidly degraded in mouse and human plasma, making it a potential novel therapy for JET.
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Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
December 2023
Volume
8
Issue
12
Start / End Page
1577 / 1588
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
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ICMJE
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Yang, Q., Tadros, H. J., Sun, B., Bidzimou, M.-T., Ezekian, J. E., Li, F., … Landstrom, A. P. (2023). Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade. JACC Basic Transl Sci, 8(12), 1577–1588. https://doi.org/10.1016/j.jacbts.2023.07.008
Yang, Qixin, Hanna J. Tadros, Bo Sun, Minu-Tshyeto Bidzimou, Jordan E. Ezekian, Feng Li, Andreas Ludwig, Xander H. T. Wehrens, and Andrew P. Landstrom. “Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade.” JACC Basic Transl Sci 8, no. 12 (December 2023): 1577–88. https://doi.org/10.1016/j.jacbts.2023.07.008.
Yang Q, Tadros HJ, Sun B, Bidzimou M-T, Ezekian JE, Li F, et al. Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade. JACC Basic Transl Sci. 2023 Dec;8(12):1577–88.
Yang, Qixin, et al. “Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade.” JACC Basic Transl Sci, vol. 8, no. 12, Dec. 2023, pp. 1577–88. Pubmed, doi:10.1016/j.jacbts.2023.07.008.
Yang Q, Tadros HJ, Sun B, Bidzimou M-T, Ezekian JE, Li F, Ludwig A, Wehrens XHT, Landstrom AP. Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade. JACC Basic Transl Sci. 2023 Dec;8(12):1577–1588.
Published In
JACC Basic Transl Sci
DOI
EISSN
2452-302X
Publication Date
December 2023
Volume
8
Issue
12
Start / End Page
1577 / 1588
Location
United States
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology