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Is gastroschisis associated with county-level socio-environmental quality during pregnancy?

Publication ,  Journal Article
Krajewski, AK; Patel, A; Gray, CL; Messer, LC; Keeler, CY; Langlois, PH; Reefhuis, J; Gilboa, SM; Werler, MM; Shaw, GM; Carmichael, SL ...
Published in: Birth defects research
November 2023

Gastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.We used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).Overall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.Future work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.

Duke Scholars

Published In

Birth defects research

DOI

EISSN

2472-1727

ISSN

2472-1727

Publication Date

November 2023

Volume

115

Issue

18

Start / End Page

1758 / 1769

Related Subject Headings

  • Prevalence
  • Pregnancy
  • Odds Ratio
  • Maternal Age
  • Infant
  • Humans
  • Gastroschisis
  • Female
  • Environmental Exposure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krajewski, A. K., Patel, A., Gray, C. L., Messer, L. C., Keeler, C. Y., Langlois, P. H., … National Birth Defects Prevention Study, . (2023). Is gastroschisis associated with county-level socio-environmental quality during pregnancy? Birth Defects Research, 115(18), 1758–1769. https://doi.org/10.1002/bdr2.2250
Krajewski, Alison K., Achal Patel, Christine L. Gray, Lynne C. Messer, Corinna Y. Keeler, Peter H. Langlois, Jennita Reefhuis, et al. “Is gastroschisis associated with county-level socio-environmental quality during pregnancy?Birth Defects Research 115, no. 18 (November 2023): 1758–69. https://doi.org/10.1002/bdr2.2250.
Krajewski AK, Patel A, Gray CL, Messer LC, Keeler CY, Langlois PH, et al. Is gastroschisis associated with county-level socio-environmental quality during pregnancy? Birth defects research. 2023 Nov;115(18):1758–69.
Krajewski, Alison K., et al. “Is gastroschisis associated with county-level socio-environmental quality during pregnancy?Birth Defects Research, vol. 115, no. 18, Nov. 2023, pp. 1758–69. Epmc, doi:10.1002/bdr2.2250.
Krajewski AK, Patel A, Gray CL, Messer LC, Keeler CY, Langlois PH, Reefhuis J, Gilboa SM, Werler MM, Shaw GM, Carmichael SL, Nembhard WN, Insaf TZ, Feldkamp ML, Conway KM, Lobdell DT, Desrosiers TA, National Birth Defects Prevention Study. Is gastroschisis associated with county-level socio-environmental quality during pregnancy? Birth defects research. 2023 Nov;115(18):1758–1769.

Published In

Birth defects research

DOI

EISSN

2472-1727

ISSN

2472-1727

Publication Date

November 2023

Volume

115

Issue

18

Start / End Page

1758 / 1769

Related Subject Headings

  • Prevalence
  • Pregnancy
  • Odds Ratio
  • Maternal Age
  • Infant
  • Humans
  • Gastroschisis
  • Female
  • Environmental Exposure