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Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.

Publication ,  Journal Article
Chen, Q; Li, K; Rhodin, KE; Bartholomew, AJ; Lidsky, ME; Wei, Q; Cai, J; Luo, S; Zhao, H
Published in: HPB (Oxford)
January 2024

BACKGROUND: Despite recommendations for primary tumor resection (PTR) with or without liver resection (LR) in the patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and isolated liver metastases, there are conflicting data for their impact on overall survival (OS). METHODS: 2320 patients with GEP-NETs and isolated liver metastases were identified from NCDB. Multiple imputations were used to accommodate missing data, and inverse probability of treatment weighting (IPTW) was conducted to minimize bias. RESULTS: Patients with PTR had a greater OS than those without PTR (3-year rate of 88.6% vs. 69.9%, P < 0.001), which was preserved in the adjusted analysis (IPTW-adjusted HR = 0.387, 95% CI: 0.264-0.567; P < 0.001). Patients with LR had a greater OS than those without LR (3-year rate 87.7% vs. 75.2%, P = 0.003), which was also preserved in adjusted analysis (IPTW-adjusted HR = 0.450, 95% CI: 0.229-0.885; P = 0.021). Patients undergoing both PTR and LR had the greatest survival advantage than those with other surgical interventions (P < 0.001). CONCLUSIONS: Either PTR or LR is associated with improved survival for GEP-NET patients with isolated liver metastases. However, there remains significant selection bias in the current study, and caution should be exercised when selecting patients for resection.

Duke Scholars

Published In

HPB (Oxford)

DOI

EISSN

1477-2574

Publication Date

January 2024

Volume

26

Issue

1

Start / End Page

125 / 136

Location

England

Related Subject Headings

  • Surgery
  • Pancreatic Neoplasms
  • Neuroendocrine Tumors
  • Metastasectomy
  • Liver Neoplasms
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Chen, Q., Li, K., Rhodin, K. E., Bartholomew, A. J., Lidsky, M. E., Wei, Q., … Zhao, H. (2024). Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival. HPB (Oxford), 26(1), 125–136. https://doi.org/10.1016/j.hpb.2023.09.016
Chen, Qichen, Kan Li, Kristen E. Rhodin, Alex J. Bartholomew, Michael E. Lidsky, Qingyi Wei, Jianqiang Cai, Sheng Luo, and Hong Zhao. “Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.HPB (Oxford) 26, no. 1 (January 2024): 125–36. https://doi.org/10.1016/j.hpb.2023.09.016.
Chen Q, Li K, Rhodin KE, Bartholomew AJ, Lidsky ME, Wei Q, et al. Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival. HPB (Oxford). 2024 Jan;26(1):125–36.
Chen, Qichen, et al. “Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.HPB (Oxford), vol. 26, no. 1, Jan. 2024, pp. 125–36. Pubmed, doi:10.1016/j.hpb.2023.09.016.
Chen Q, Li K, Rhodin KE, Bartholomew AJ, Lidsky ME, Wei Q, Cai J, Luo S, Zhao H. Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival. HPB (Oxford). 2024 Jan;26(1):125–136.

Published In

HPB (Oxford)

DOI

EISSN

1477-2574

Publication Date

January 2024

Volume

26

Issue

1

Start / End Page

125 / 136

Location

England

Related Subject Headings

  • Surgery
  • Pancreatic Neoplasms
  • Neuroendocrine Tumors
  • Metastasectomy
  • Liver Neoplasms
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences