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Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association.

Publication ,  Journal Article
Ndumele, CE; Rangaswami, J; Chow, SL; Neeland, IJ; Tuttle, KR; Khan, SS; Coresh, J; Mathew, RO; Baker-Smith, CM; Carnethon, MR; Despres, J-P ...
Published in: Circulation
November 14, 2023

Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors, chronic kidney disease, and the cardiovascular system and has profound impacts on morbidity and mortality. There are multisystem consequences of poor cardiovascular-kidney-metabolic health, with the most significant clinical impact being the high associated incidence of cardiovascular disease events and cardiovascular mortality. There is a high prevalence of poor cardiovascular-kidney-metabolic health in the population, with a disproportionate burden seen among those with adverse social determinants of health. However, there is also a growing number of therapeutic options that favorably affect metabolic risk factors, kidney function, or both that also have cardioprotective effects. To improve cardiovascular-kidney-metabolic health and related outcomes in the population, there is a critical need for (1) more clarity on the definition of cardiovascular-kidney-metabolic syndrome; (2) an approach to cardiovascular-kidney-metabolic staging that promotes prevention across the life course; (3) prediction algorithms that include the exposures and outcomes most relevant to cardiovascular-kidney-metabolic health; and (4) strategies for the prevention and management of cardiovascular disease in relation to cardiovascular-kidney-metabolic health that reflect harmonization across major subspecialty guidelines and emerging scientific evidence. It is also critical to incorporate considerations of social determinants of health into care models for cardiovascular-kidney-metabolic syndrome and to reduce care fragmentation by facilitating approaches for patient-centered interdisciplinary care. This presidential advisory provides guidance on the definition, staging, prediction paradigms, and holistic approaches to care for patients with cardiovascular-kidney-metabolic syndrome and details a multicomponent vision for effectively and equitably enhancing cardiovascular-kidney-metabolic health in the population.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 14, 2023

Volume

148

Issue

20

Start / End Page

1606 / 1635

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Metabolic Syndrome
  • Kidney
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular System
  • Cardiovascular Diseases
  • American Heart Association
  • 4207 Sports science and exercise
 

Citation

APA
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Ndumele, C. E., Rangaswami, J., Chow, S. L., Neeland, I. J., Tuttle, K. R., Khan, S. S., … American Heart Association, . (2023). Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation, 148(20), 1606–1635. https://doi.org/10.1161/CIR.0000000000001184
Ndumele, Chiadi E., Janani Rangaswami, Sheryl L. Chow, Ian J. Neeland, Katherine R. Tuttle, Sadiya S. Khan, Josef Coresh, et al. “Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association.Circulation 148, no. 20 (November 14, 2023): 1606–35. https://doi.org/10.1161/CIR.0000000000001184.
Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, et al. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation. 2023 Nov 14;148(20):1606–35.
Ndumele, Chiadi E., et al. “Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association.Circulation, vol. 148, no. 20, Nov. 2023, pp. 1606–35. Pubmed, doi:10.1161/CIR.0000000000001184.
Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, Coresh J, Mathew RO, Baker-Smith CM, Carnethon MR, Despres J-P, Ho JE, Joseph JJ, Kernan WN, Khera A, Kosiborod MN, Lekavich CL, Lewis EF, Lo KB, Ozkan B, Palaniappan LP, Patel SS, Pencina MJ, Powell-Wiley TM, Sperling LS, Virani SS, Wright JT, Rajgopal Singh R, Elkind MSV, American Heart Association. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation. 2023 Nov 14;148(20):1606–1635.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 14, 2023

Volume

148

Issue

20

Start / End Page

1606 / 1635

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Metabolic Syndrome
  • Kidney
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular System
  • Cardiovascular Diseases
  • American Heart Association
  • 4207 Sports science and exercise