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A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.

Publication ,  Journal Article
Ndumele, CE; Neeland, IJ; Tuttle, KR; Chow, SL; Mathew, RO; Khan, SS; Coresh, J; Baker-Smith, CM; Carnethon, MR; Després, J-P; Ho, JE; Lo, KB ...
Published in: Circulation
November 14, 2023

A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led to the conceptualization of cardiovascular-kidney-metabolic syndrome. The confluence of metabolic risk factors and chronic kidney disease within cardiovascular-kidney-metabolic syndrome is strongly linked to risk for adverse cardiovascular and kidney outcomes. In addition, there are unique management considerations for individuals with established cardiovascular disease and coexisting metabolic risk factors, chronic kidney disease, or both. An extensive body of literature supports our scientific understanding of, and approach to, prevention and management for individuals with cardiovascular-kidney-metabolic syndrome. However, there are critical gaps in knowledge related to cardiovascular-kidney-metabolic syndrome in terms of mechanisms of disease development, heterogeneity within clinical phenotypes, interplay between social determinants of health and biological risk factors, and accurate assessments of disease incidence in the context of competing risks. There are also key limitations in the data supporting the clinical care for cardiovascular-kidney-metabolic syndrome, particularly in terms of early-life prevention, screening for risk factors, interdisciplinary care models, optimal strategies for supporting lifestyle modification and weight loss, targeting of emerging cardioprotective and kidney-protective therapies, management of patients with both cardiovascular disease and chronic kidney disease, and the impact of systematically assessing and addressing social determinants of health. This scientific statement uses a crosswalk of major guidelines, in addition to a review of the scientific literature, to summarize the evidence and fundamental gaps related to the science, screening, prevention, and management of cardiovascular-kidney-metabolic syndrome.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 14, 2023

Volume

148

Issue

20

Start / End Page

1636 / 1664

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Metabolic Syndrome
  • Kidney
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • American Heart Association
  • 4207 Sports science and exercise
 

Citation

APA
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Ndumele, C. E., Neeland, I. J., Tuttle, K. R., Chow, S. L., Mathew, R. O., Khan, S. S., … American Heart Association, . (2023). A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. Circulation, 148(20), 1636–1664. https://doi.org/10.1161/CIR.0000000000001186
Ndumele, Chiadi E., Ian J. Neeland, Katherine R. Tuttle, Sheryl L. Chow, Roy O. Mathew, Sadiya S. Khan, Josef Coresh, et al. “A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.Circulation 148, no. 20 (November 14, 2023): 1636–64. https://doi.org/10.1161/CIR.0000000000001186.
Ndumele, Chiadi E., et al. “A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.Circulation, vol. 148, no. 20, Nov. 2023, pp. 1636–64. Pubmed, doi:10.1161/CIR.0000000000001186.
Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, Coresh J, Baker-Smith CM, Carnethon MR, Després J-P, Ho JE, Joseph JJ, Kernan WN, Khera A, Kosiborod MN, Lekavich CL, Lewis EF, Lo KB, Ozkan B, Palaniappan LP, Patel SS, Pencina MJ, Powell-Wiley TM, Sperling LS, Virani SS, Wright JT, Rajgopal Singh R, Elkind MSV, Rangaswami J, American Heart Association. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. Circulation. 2023 Nov 14;148(20):1636–1664.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 14, 2023

Volume

148

Issue

20

Start / End Page

1636 / 1664

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Metabolic Syndrome
  • Kidney
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • American Heart Association
  • 4207 Sports science and exercise