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Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.

Publication ,  Journal Article
Monangi, NK; Xu, H; Fan, Y-M; Khanam, R; Khan, W; Deb, S; Pervin, J; Price, JT; Kaur, L; INTERBIO-21st Study Consortium, ; Al Mahmud, A ...
Published in: Am J Clin Nutr
January 2024

BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations. METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort. RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration. CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.

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Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

January 2024

Volume

119

Issue

1

Start / End Page

221 / 231

Location

United States

Related Subject Headings

  • Risk Factors
  • Premature Birth
  • Pregnancy
  • Nutrition & Dietetics
  • Live Birth
  • Inflammation
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Monangi, N. K., Xu, H., Fan, Y.-M., Khanam, R., Khan, W., Deb, S., … Muglia, L. J. (2024). Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. Am J Clin Nutr, 119(1), 221–231. https://doi.org/10.1016/j.ajcnut.2023.10.011
Monangi, Nagendra K., Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, et al. “Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.Am J Clin Nutr 119, no. 1 (January 2024): 221–31. https://doi.org/10.1016/j.ajcnut.2023.10.011.
Monangi NK, Xu H, Fan Y-M, Khanam R, Khan W, Deb S, et al. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. Am J Clin Nutr. 2024 Jan;119(1):221–31.
Monangi, Nagendra K., et al. “Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.Am J Clin Nutr, vol. 119, no. 1, Jan. 2024, pp. 221–31. Pubmed, doi:10.1016/j.ajcnut.2023.10.011.
Monangi NK, Xu H, Fan Y-M, Khanam R, Khan W, Deb S, Pervin J, Price JT, Kaur L, INTERBIO-21st Study Consortium, Al Mahmud A, Thanh LQ, Care A, Landero JA, Combs GF, Belling E, Chappell J, Chen J, Kong F, Lacher C, Ahmed S, Chowdhury NH, Rahman S, Kabir F, Nisar I, Hotwani A, Mehmood U, Nizar A, Khalid J, Dhingra U, Dutta A, Ali SM, Aftab F, Juma MH, Rahman M, Ahmed T, Islam MM, Vwalika B, Musonda P, Ashorn U, Maleta K, Hallman M, Goodfellow L, Gupta JK, Alfirevic A, Murphy SK, Rand L, Ryckman KK, Murray JC, Bahl R, Litch JA, Baruch-Gravett C, Sopory S, Chandra Mouli Natchu U, Kumar PV, Kumari N, Thiruvengadam R, Singh AK, Kumar P, GARBH-Ini study team, Alfirevic Z, Baqui AH, Bhatnagar S, Hirst JE, Hoyo C, Jehan F, Jelliffe-Pawlowski L, Rahman A, Roth DE, Sazawal S, Stringer JSA, Ashorn P, Zhang G, Muglia LJ. Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. Am J Clin Nutr. 2024 Jan;119(1):221–231.
Journal cover image

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

January 2024

Volume

119

Issue

1

Start / End Page

221 / 231

Location

United States

Related Subject Headings

  • Risk Factors
  • Premature Birth
  • Pregnancy
  • Nutrition & Dietetics
  • Live Birth
  • Inflammation
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female