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Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.

Publication ,  Journal Article
Liao, J; Zhang, Y; Yang, Z; Qiu, C; Chen, W; Zhang, JJ; Berhane, K; Bai, Z; Han, B; Xu, J; Jiang, Y-H; Gilliland, F; Yan, W; Huang, G; Chen, Z
Published in: Environmental health : a global access science source
October 2023

Few studies have assessed air pollution exposure association with birthweight during both preconception and gestational periods.Leveraging a preconception cohort consisting of 14220 pregnant women and newborn children in Shanghai, China during 2016-2018, we aim to assess associations of NO2 and PM2.5 exposure, derived from high-resolution spatial-temporal models, during preconception and gestational periods with outcomes including term birthweight, birthweight Z-score, small-for-gestational age (SGA) and large-for-gestational age (LGA). Linear and logistic regressions were used to estimate 3-month preconception and trimester-averaged air pollution exposure associations; and distributed lag models (DLM) were used to identify critical exposure windows at the weekly resolution from preconception to delivery. Two-pollutant models and children's sex-specific associations were explored.After controlling for covariates, one standard deviation (SD) (11.5 μg/m3, equivalent to 6.1 ppb) increase in NO2 exposure during the second and the third trimester was associated with 13% (95% confidence interval: 2 - 26%) and 14% (95% CI: 1 - 29%) increase in SGA, respectively; and one SD (9.6 μg/m3) increase in PM2.5 exposure during the third trimester was associated with 15% (95% CI: 1 - 31%) increase in SGA. No association have been found for outcomes of birthweight, birthweight Z-score and LGA. DLM found that gestational weeks 22-32 were a critical window, when NO2 exposure had strongest associations with SGA. The associations of air pollution exposure tended to be stronger in female newborns than in male newborns. However, no significant associations of air pollution exposure during preconception period on birthweight outcomes were found.Consistent with previous studies, we found that air pollution exposure during mid-to-late pregnancy was associated with adverse birthweight outcomes.

Duke Scholars

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Published In

Environmental health : a global access science source

DOI

EISSN

1476-069X

ISSN

1476-069X

Publication Date

October 2023

Volume

22

Issue

1

Start / End Page

71

Related Subject Headings

  • Toxicology
  • Prospective Studies
  • Pregnancy
  • Particulate Matter
  • Nitrogen Dioxide
  • Maternal Exposure
  • Male
  • Infant, Newborn
  • Humans
  • Fetal Growth Retardation
 

Citation

APA
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Liao, J., Zhang, Y., Yang, Z., Qiu, C., Chen, W., Zhang, J. J., … Chen, Z. (2023). Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study. Environmental Health : A Global Access Science Source, 22(1), 71. https://doi.org/10.1186/s12940-023-01022-6
Liao, Jiawen, Yi Zhang, Zhenchun Yang, Chenyu Qiu, Wu Chen, Junfeng Jim Zhang, Kiros Berhane, et al. “Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.Environmental Health : A Global Access Science Source 22, no. 1 (October 2023): 71. https://doi.org/10.1186/s12940-023-01022-6.
Liao J, Zhang Y, Yang Z, Qiu C, Chen W, Zhang JJ, et al. Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study. Environmental health : a global access science source. 2023 Oct;22(1):71.
Liao, Jiawen, et al. “Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.Environmental Health : A Global Access Science Source, vol. 22, no. 1, Oct. 2023, p. 71. Epmc, doi:10.1186/s12940-023-01022-6.
Liao J, Zhang Y, Yang Z, Qiu C, Chen W, Zhang JJ, Berhane K, Bai Z, Han B, Xu J, Jiang Y-H, Gilliland F, Yan W, Huang G, Chen Z. Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study. Environmental health : a global access science source. 2023 Oct;22(1):71.
Journal cover image

Published In

Environmental health : a global access science source

DOI

EISSN

1476-069X

ISSN

1476-069X

Publication Date

October 2023

Volume

22

Issue

1

Start / End Page

71

Related Subject Headings

  • Toxicology
  • Prospective Studies
  • Pregnancy
  • Particulate Matter
  • Nitrogen Dioxide
  • Maternal Exposure
  • Male
  • Infant, Newborn
  • Humans
  • Fetal Growth Retardation