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Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.

Publication ,  Journal Article
Spratt, DE; Tang, S; Sun, Y; Huang, H-C; Chen, E; Mohamad, O; Armstrong, AJ; Tward, JD; Nguyen, PL; Lang, JM; Zhang, J; Mitani, A; Simko, JP ...
Published in: Res Sq
April 21, 2023

BACKGROUND: Androgen deprivation therapy (ADT) with radiotherapy can benefit patients with localized prostate cancer. However, ADT can negatively impact quality of life and there remain no validated predictive models to guide its use. METHODS: Digital pathology image and clinical data from pre-treatment prostate tissue from 5,727 patients enrolled on five phase III randomized trials treated with radiotherapy +/- ADT were used to develop and validate an artificial intelligence (AI)-derived predictive model to assess ADT benefit with the primary endpoint of distant metastasis. After the model was locked, validation was performed on NRG/RTOG 9408 (n = 1,594) that randomized men to radiotherapy +/- 4 months of ADT. Fine-Gray regression and restricted mean survival times were used to assess the interaction between treatment and predictive model and within predictive model positive and negative subgroup treatment effects. RESULTS: In the NRG/RTOG 9408 validation cohort (14.9 years of median follow-up), ADT significantly improved time to distant metastasis (subdistribution hazard ratio [sHR] = 0.64, 95%CI [0.45-0.90], p = 0.01). The predictive model-treatment interaction was significant (p-interaction = 0.01). In predictive model positive patients (n = 543, 34%), ADT significantly reduced the risk of distant metastasis compared to radiotherapy alone (sHR = 0.34, 95%CI [0.19-0.63], p < 0.001). There were no significant differences between treatment arms in the predictive model negative subgroup (n = 1,051, 66%; sHR = 0.92, 95%CI [0.59-1.43], p = 0.71). CONCLUSIONS: Our data, derived and validated from completed randomized phase III trials, show that an AI-based predictive model was able to identify prostate cancer patients, with predominately intermediate-risk disease, who are likely to benefit from short-term ADT.

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Published In

Res Sq

DOI

Publication Date

April 21, 2023

Location

United States
 

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Spratt, D. E., Tang, S., Sun, Y., Huang, H.-C., Chen, E., Mohamad, O., … Feng, F. Y. (2023). Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer. Res Sq. https://doi.org/10.21203/rs.3.rs-2790858/v1
Spratt, Daniel E., Siyi Tang, Yilun Sun, Huei-Chung Huang, Emmalyn Chen, Osama Mohamad, Andrew J. Armstrong, et al. “Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.Res Sq, April 21, 2023. https://doi.org/10.21203/rs.3.rs-2790858/v1.
Spratt DE, Tang S, Sun Y, Huang H-C, Chen E, Mohamad O, et al. Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer. Res Sq. 2023 Apr 21;
Spratt, Daniel E., et al. “Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.Res Sq, Apr. 2023. Pubmed, doi:10.21203/rs.3.rs-2790858/v1.
Spratt DE, Tang S, Sun Y, Huang H-C, Chen E, Mohamad O, Armstrong AJ, Tward JD, Nguyen PL, Lang JM, Zhang J, Mitani A, Simko JP, DeVries S, van der Wal D, Pinckaers H, Monson JM, Campbell HA, Wallace J, Ferguson MJ, Bahary J-P, Schaeffer EM, NRG Prostate Cancer AI Consortium, Sandler HM, Tran PT, Rodgers JP, Esteva A, Yamashita R, Feng FY. Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer. Res Sq. 2023 Apr 21;

Published In

Res Sq

DOI

Publication Date

April 21, 2023

Location

United States