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Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking.

Publication ,  Journal Article
Miceli, K; Morales-Torres, R; Khoudary, A; Faul, L; Parikh, N; De Brigard, F
Published in: Hippocampus
January 2024

Episodic counterfactual thinking (ECT) consists of imagining alternative outcomes to past personal events. Previous research has shown that ECT shares common neural substrates with episodic future thinking (EFT): our ability to imagine possible future events. Both ECT and EFT have been shown to critically depend on the hippocampus, and past research has explored hippocampal engagement as a function of the perceived plausibility of an imagined future event. However, the extent to which the hippocampus is modulated by perceived plausibility during ECT is unknown. In this study, we combine two functional magnetic resonance imaging datasets to investigate whether perceived plausibility modulates hippocampal activity during ECT. Our results indicate that plausibility parametrically modulates hippocampal activity during ECT, and that such modulation is confined to the left anterior portion of the hippocampus. Moreover, our results indicate that this modulation is positive, such that increased activity in the left anterior hippocampus is associated with higher ratings of ECT plausibility. We suggest that neither effort nor difficulty alone can account for these results, and instead suggest possible alternatives to explain the role of the hippocampus during the construction of plausible and implausible ECT.

Duke Scholars

Published In

Hippocampus

DOI

EISSN

1098-1063

ISSN

1050-9631

Publication Date

January 2024

Volume

34

Issue

1

Start / End Page

2 / 6

Related Subject Headings

  • Thinking
  • Temporal Lobe
  • Neurology & Neurosurgery
  • Memory, Episodic
  • Magnetic Resonance Imaging
  • Imagination
  • Hippocampus
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Miceli, K., Morales-Torres, R., Khoudary, A., Faul, L., Parikh, N., & De Brigard, F. (2024). Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking. Hippocampus, 34(1), 2–6. https://doi.org/10.1002/hipo.23583
Miceli, Kaylee, Ricardo Morales-Torres, Ari Khoudary, Leonard Faul, Natasha Parikh, and Felipe De Brigard. “Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking.Hippocampus 34, no. 1 (January 2024): 2–6. https://doi.org/10.1002/hipo.23583.
Miceli K, Morales-Torres R, Khoudary A, Faul L, Parikh N, De Brigard F. Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking. Hippocampus. 2024 Jan;34(1):2–6.
Miceli, Kaylee, et al. “Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking.Hippocampus, vol. 34, no. 1, Jan. 2024, pp. 2–6. Epmc, doi:10.1002/hipo.23583.
Miceli K, Morales-Torres R, Khoudary A, Faul L, Parikh N, De Brigard F. Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking. Hippocampus. 2024 Jan;34(1):2–6.
Journal cover image

Published In

Hippocampus

DOI

EISSN

1098-1063

ISSN

1050-9631

Publication Date

January 2024

Volume

34

Issue

1

Start / End Page

2 / 6

Related Subject Headings

  • Thinking
  • Temporal Lobe
  • Neurology & Neurosurgery
  • Memory, Episodic
  • Magnetic Resonance Imaging
  • Imagination
  • Hippocampus
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences