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Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD.

Publication ,  Journal Article
Romero-Gutierrez, C; Koutrakis, P; Liu, M; Zilli Vieira, CL; Coull, BA; Maher, EF; Zhang, JJ; Garshick, E
Published in: Environmental research
January 2024

Radon decay products include α-radiation emitting radionuclides that attach to airborne particles that have potential to promote oxidative tissue damage after inhalation. To assess associations between α-particle radioactivity (α-PR) with urinary biomarkers of oxidative tissue damage, 140 patients with chronic obstructive pulmonary disease (COPD) had up to four 1-week seasonal assessments (N = 413) of indoor (home) and ambient (central site) PM2.5 and black carbon (BC). Following environmental sampling, urine samples were analyzed for total and free malondialdehyde (MDA), biomarkers of lipid oxidation, and 8-hydroxyl-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage. Particle radioactivity was measured as α-activity on PM2.5 filter samples. Linear mixed-effects regression models adjusted for urinary creatinine and other personal characteristics were used to assess associations. Indoor α-PR was associated with an increase in 8-OhdG (8.53%; 95% CI: 3.12, 14.23); total MDA (5.59%; 95% CI: 0.20, 11.71); and free MDA (2.17%; 95% CI: 2.75, 7.35) per interquartile range (IQR) of α-PR [median 1.25 mBq/m3; IQR 0.64], similar adjusting for PM2.5 or BC. The ratio of indoor/ambient α-PR was positively associated with each biomarker and associations with ambient α-PR were positive but weaker than with indoor concentrations. These findings are consistent with a contribution of radon decay products as measured by α-PR to oxidative stress in patients with COPD, with a greater contribution of indoor radon decay products.

Duke Scholars

Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

January 2024

Volume

240

Issue

Pt 2

Start / End Page

117505

Related Subject Headings

  • Toxicology
  • Soot
  • Radon Daughters
  • Radon
  • Radioactivity
  • Pulmonary Disease, Chronic Obstructive
  • Oxidative Stress
  • Humans
  • Biomarkers
  • 41 Environmental sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Romero-Gutierrez, C., Koutrakis, P., Liu, M., Zilli Vieira, C. L., Coull, B. A., Maher, E. F., … Garshick, E. (2024). Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD. Environmental Research, 240(Pt 2), 117505. https://doi.org/10.1016/j.envres.2023.117505
Romero-Gutierrez, Christopher, Petros Koutrakis, Man Liu, Carolina L. Zilli Vieira, Brent A. Coull, Edward F. Maher, Junfeng Jim Zhang, and Eric Garshick. “Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD.Environmental Research 240, no. Pt 2 (January 2024): 117505. https://doi.org/10.1016/j.envres.2023.117505.
Romero-Gutierrez C, Koutrakis P, Liu M, Zilli Vieira CL, Coull BA, Maher EF, et al. Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD. Environmental research. 2024 Jan;240(Pt 2):117505.
Romero-Gutierrez, Christopher, et al. “Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD.Environmental Research, vol. 240, no. Pt 2, Jan. 2024, p. 117505. Epmc, doi:10.1016/j.envres.2023.117505.
Romero-Gutierrez C, Koutrakis P, Liu M, Zilli Vieira CL, Coull BA, Maher EF, Zhang JJ, Garshick E. Radon decay product particle radioactivity and oxidative stress biomarkers in patients with COPD. Environmental research. 2024 Jan;240(Pt 2):117505.
Journal cover image

Published In

Environmental research

DOI

EISSN

1096-0953

ISSN

0013-9351

Publication Date

January 2024

Volume

240

Issue

Pt 2

Start / End Page

117505

Related Subject Headings

  • Toxicology
  • Soot
  • Radon Daughters
  • Radon
  • Radioactivity
  • Pulmonary Disease, Chronic Obstructive
  • Oxidative Stress
  • Humans
  • Biomarkers
  • 41 Environmental sciences