Scholars@Duke publication: Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome.

Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome.

Publication , Journal Article

Bazan, NG; Scott, BL; Reddy, TS; Pelias, MZ

Published in: Biochem Biophys Res Commun

December 15, 1986

Docosahexaenoate and arachidonate were found to be significantly decreased in plasma phospholipids from Usher's syndrome patients. The fatty acid content of plasma triacylglycerols was not changed in these patients. Usher's syndrome, an autosomal recessive disorder, involves an inherited visual cell degeneration. Photoreceptor membranes are richly endowed with docosahexaenoate and arachidonate, and a metabolic defect affecting these polyunsaturated fatty acids may occur. Moreover, blindness may be due, at least partially, to an alteration in the unsaturated phospholipids of photoreceptor membranes.

Duke Scholars

Author Burton Lasater Scott Neurology, Movement Disorders

Published In

Biochem Biophys Res Commun

DOI

10.1016/s0006-291x(86)80215-7

ISSN

0006-291X

Publication Date

December 15, 1986

Volume

141

Issue

Start / End Page

600 / 604

Location

United States

Related Subject Headings

Triglycerides
Syndrome
Retinitis Pigmentosa
Photoreceptor Cells
Phospholipids
Humans
Fatty Acids, Unsaturated
Docosahexaenoic Acids
Biochemistry & Molecular Biology
Arachidonic Acids

Citation

APA

Chicago

ICMJE

MLA

NLM

Bazan, N. G., Scott, B. L., Reddy, T. S., & Pelias, M. Z. (1986). Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. Biochem Biophys Res Commun, 141(2), 600–604. https://doi.org/10.1016/s0006-291x(86)80215-7

Bazan, N. G., B. L. Scott, T. S. Reddy, and M. Z. Pelias. “Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome.” Biochem Biophys Res Commun 141, no. 2 (December 15, 1986): 600–604. https://doi.org/10.1016/s0006-291x(86)80215-7.

Bazan NG, Scott BL, Reddy TS, Pelias MZ. Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. Biochem Biophys Res Commun. 1986 Dec 15;141(2):600–4.

Bazan, N. G., et al. “Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome.” Biochem Biophys Res Commun, vol. 141, no. 2, Dec. 1986, pp. 600–04. Pubmed, doi:10.1016/s0006-291x(86)80215-7.

Bazan NG, Scott BL, Reddy TS, Pelias MZ. Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. Biochem Biophys Res Commun. 1986 Dec 15;141(2):600–604.