NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023.
Novel targeted therapies (small molecule inhibitors, antibody-drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton's tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.
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Related Subject Headings
- T-Lymphocytes
- Oncology & Carcinogenesis
- Lymphoma, Mantle-Cell
- Lymphoma, Large B-Cell, Diffuse
- Lymphoma, Follicular
- Immunotherapy, Adoptive
- Humans
- Adult
- 4203 Health services and systems
- 3211 Oncology and carcinogenesis
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- T-Lymphocytes
- Oncology & Carcinogenesis
- Lymphoma, Mantle-Cell
- Lymphoma, Large B-Cell, Diffuse
- Lymphoma, Follicular
- Immunotherapy, Adoptive
- Humans
- Adult
- 4203 Health services and systems
- 3211 Oncology and carcinogenesis