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Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies.

Publication ,  Journal Article
Caspi, A; Shireby, G; Mill, J; Moffitt, TE; Sugden, K; Hannon, E
Published in: Biological psychiatry
November 2023

Schizophrenia is associated with increased risk of developing multiple aging-related diseases, including metabolic, respiratory, and cardiovascular diseases, and Alzheimer's and related dementias, leading to the hypothesis that schizophrenia is accompanied by accelerated biological aging. This has been difficult to test because there is no widely accepted measure of biological aging. Epigenetic clocks are promising algorithms that are used to calculate biological age on the basis of information from combined cytosine-phosphate-guanine sites (CpGs) across the genome, but they have yielded inconsistent and often negative results about the association between schizophrenia and accelerated aging. Here, we tested the schizophrenia-aging hypothesis using a DNA methylation measure that is uniquely designed to predict an individual's rate of aging.We brought together 5 case-control datasets to calculate DunedinPACE (Pace of Aging Calculated from the Epigenome), a new measure trained on longitudinal data to detect differences between people in their pace of aging over time. Data were available from 1812 psychosis cases (schizophrenia or first-episode psychosis) and 1753 controls. Mean chronological age was 38.9 (SD = 13.6) years.We observed consistent associations across datasets between schizophrenia and accelerated aging as measured by DunedinPACE. These associations were not attributable to tobacco smoking or clozapine medication.Schizophrenia is accompanied by accelerated biological aging by midlife. This may explain the wide-ranging risk among people with schizophrenia for developing multiple different age-related physical diseases, including metabolic, respiratory, and cardiovascular diseases, and dementia. Measures of biological aging could prove valuable for assessing patients' risk for physical and cognitive decline and for evaluating intervention effectiveness.

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Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

November 2023

Start / End Page

S0006-3223(23)01693-1

Related Subject Headings

  • Psychiatry
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Caspi, A., Shireby, G., Mill, J., Moffitt, T. E., Sugden, K., & Hannon, E. (2023). Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies. Biological Psychiatry, S0006-3223(23)01693-1. https://doi.org/10.1016/j.biopsych.2023.10.023
Caspi, Avshalom, Gemma Shireby, Jonathan Mill, Terrie E. Moffitt, Karen Sugden, and Eilis Hannon. “Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies.Biological Psychiatry, November 2023, S0006-3223(23)01693-1. https://doi.org/10.1016/j.biopsych.2023.10.023.
Caspi A, Shireby G, Mill J, Moffitt TE, Sugden K, Hannon E. Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies. Biological psychiatry. 2023 Nov;S0006-3223(23)01693-1.
Caspi, Avshalom, et al. “Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies.Biological Psychiatry, Nov. 2023, pp. S0006-3223(23)01693-1. Epmc, doi:10.1016/j.biopsych.2023.10.023.
Caspi A, Shireby G, Mill J, Moffitt TE, Sugden K, Hannon E. Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies. Biological psychiatry. 2023 Nov;S0006-3223(23)01693–1.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

November 2023

Start / End Page

S0006-3223(23)01693-1

Related Subject Headings

  • Psychiatry
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences