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Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.

Publication ,  Journal Article
Chen, O; Luo, X; Ji, R-R
Published in: Med Rev (2021)
October 2023

Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types, representing immune cells and glial cells, respectively, but they share similar roles in pain regulation. Macrophages are key regulators of inflammation and pain. Macrophage polarization plays different roles in inducing and resolving pain. Notably, macrophage polarization and phagocytosis can be induced by specialized pro-resolution mediators (SPMs). SPMs also potently inhibit inflammatory and neuropathic pain via immunomodulation and neuromodulation. In this review, we discuss macrophage signaling involved in pain induction and resolution, as well as in maintaining physiological pain. Microglia are macrophage-like cells in the central nervous system (CNS) and drive neuroinflammation and pathological pain in various inflammatory and neurological disorders. Microglia-produced inflammatory cytokines can potently regulate excitatory and inhibitory synaptic transmission as neuromodulators. We also highlight sex differences in macrophage and microglial signaling in inflammatory and neuropathic pain. Thus, targeting macrophage and microglial signaling in distinct locations via pharmacological approaches, including immunotherapies, and non-pharmacological approaches will help to control chronic inflammation and chronic pain.

Duke Scholars

Published In

Med Rev (2021)

DOI

EISSN

2749-9642

Publication Date

October 2023

Volume

3

Issue

5

Start / End Page

381 / 407

Location

Germany
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, O., Luo, X., & Ji, R.-R. (2023). Macrophages and microglia in inflammation and neuroinflammation underlying different pain states. Med Rev (2021), 3(5), 381–407. https://doi.org/10.1515/mr-2023-0034
Chen, Ouyang, Xin Luo, and Ru-Rong Ji. “Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.Med Rev (2021) 3, no. 5 (October 2023): 381–407. https://doi.org/10.1515/mr-2023-0034.
Chen, Ouyang, et al. “Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.Med Rev (2021), vol. 3, no. 5, Oct. 2023, pp. 381–407. Pubmed, doi:10.1515/mr-2023-0034.

Published In

Med Rev (2021)

DOI

EISSN

2749-9642

Publication Date

October 2023

Volume

3

Issue

5

Start / End Page

381 / 407

Location

Germany