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A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.

Publication ,  Journal Article
Matthews, EA; Harward, S; Marek, J; Drysdale, ND; Schuetz, E; Krishnamurthy, K; McNamara, JO
Published in: Epilepsy Res
December 2023

The lack of preventive and disease modifying therapies for temporal lobe epilepsy (TLE) is a major unmet medical need. Search for such therapies utilize mouse models and require detection of seizures in electroencephalography (EEG) recordings. The labor-intensive nature of reviewing EEGs spanning many weeks underscores the need for a method of automated detection. Here we report a simple automated method of detecting seizures in long term EEG recordings from electrodes implanted in the hippocampus in animal models of TLE. We utilize a 2-pronged approach that relies on the increase in power within the gamma band range (20-50hz) during the seizure followed by suppression of activity following the seizure (post-ictal suppression [PIS]). We demonstrate the utility of this method for detecting seizures in hippocampal and amygdala EEG recordings from multiple models of TLE.

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Published In

Epilepsy Res

DOI

EISSN

1872-6844

Publication Date

December 2023

Volume

198

Start / End Page

107256

Location

Netherlands

Related Subject Headings

  • Seizures
  • Neurology & Neurosurgery
  • Mice
  • Hippocampus
  • Epilepsy, Temporal Lobe
  • Electroencephalography
  • Disease Models, Animal
  • Animals
  • Amygdala
  • 5203 Clinical and health psychology
 

Citation

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Matthews, E. A., Harward, S., Marek, J., Drysdale, N. D., Schuetz, E., Krishnamurthy, K., & McNamara, J. O. (2023). A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy. Epilepsy Res, 198, 107256. https://doi.org/10.1016/j.eplepsyres.2023.107256
Matthews, Elizabeth A., Steve Harward, Josh Marek, Nicolas D. Drysdale, Elizabeth Schuetz, Kamesh Krishnamurthy, and James O. McNamara. “A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.Epilepsy Res 198 (December 2023): 107256. https://doi.org/10.1016/j.eplepsyres.2023.107256.
Matthews EA, Harward S, Marek J, Drysdale ND, Schuetz E, Krishnamurthy K, et al. A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy. Epilepsy Res. 2023 Dec;198:107256.
Matthews, Elizabeth A., et al. “A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.Epilepsy Res, vol. 198, Dec. 2023, p. 107256. Pubmed, doi:10.1016/j.eplepsyres.2023.107256.
Matthews EA, Harward S, Marek J, Drysdale ND, Schuetz E, Krishnamurthy K, McNamara JO. A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy. Epilepsy Res. 2023 Dec;198:107256.
Journal cover image

Published In

Epilepsy Res

DOI

EISSN

1872-6844

Publication Date

December 2023

Volume

198

Start / End Page

107256

Location

Netherlands

Related Subject Headings

  • Seizures
  • Neurology & Neurosurgery
  • Mice
  • Hippocampus
  • Epilepsy, Temporal Lobe
  • Electroencephalography
  • Disease Models, Animal
  • Animals
  • Amygdala
  • 5203 Clinical and health psychology