Evolution of the SARS-CoV-2 Omicron spike.
Publication
, Journal Article
Parsons, RJ; Acharya, P
Published in: Cell Rep
December 26, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern, first identified in November 2021, rapidly spread worldwide and diversified into several subvariants. The Omicron spike (S) protein accumulated an unprecedented number of sequence changes relative to previous variants. In this review, we discuss how Omicron S protein structural features modulate host cell receptor binding, virus entry, and immune evasion and highlight how these structural features differentiate Omicron from previous variants. We also examine how key structural properties track across the still-evolving Omicron subvariants and the importance of continuing surveillance of the S protein sequence evolution over time.
Duke Scholars
Published In
Cell Rep
DOI
EISSN
2211-1247
Publication Date
December 26, 2023
Volume
42
Issue
12
Start / End Page
113444
Location
United States
Related Subject Headings
- SARS-CoV-2
- Immune Evasion
- Humans
- COVID-19
- 31 Biological sciences
- 1116 Medical Physiology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Parsons, R. J., & Acharya, P. (2023). Evolution of the SARS-CoV-2 Omicron spike. Cell Rep, 42(12), 113444. https://doi.org/10.1016/j.celrep.2023.113444
Parsons, Ruth J., and Priyamvada Acharya. “Evolution of the SARS-CoV-2 Omicron spike.” Cell Rep 42, no. 12 (December 26, 2023): 113444. https://doi.org/10.1016/j.celrep.2023.113444.
Parsons RJ, Acharya P. Evolution of the SARS-CoV-2 Omicron spike. Cell Rep. 2023 Dec 26;42(12):113444.
Parsons, Ruth J., and Priyamvada Acharya. “Evolution of the SARS-CoV-2 Omicron spike.” Cell Rep, vol. 42, no. 12, Dec. 2023, p. 113444. Pubmed, doi:10.1016/j.celrep.2023.113444.
Parsons RJ, Acharya P. Evolution of the SARS-CoV-2 Omicron spike. Cell Rep. 2023 Dec 26;42(12):113444.
Published In
Cell Rep
DOI
EISSN
2211-1247
Publication Date
December 26, 2023
Volume
42
Issue
12
Start / End Page
113444
Location
United States
Related Subject Headings
- SARS-CoV-2
- Immune Evasion
- Humans
- COVID-19
- 31 Biological sciences
- 1116 Medical Physiology
- 0601 Biochemistry and Cell Biology