Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke.

Publication ,  Journal Article
Wilson, KL; Joseph, NI; Onweller, LA; Anderson, AR; Darling, NJ; David-Bercholz, J; Segura, T
Published in: Advanced healthcare materials
November 2023

Angiogenesis after stroke is correlated with enhanced tissue repair and functional outcomes. The existing body of research in biomaterials for stroke focuses on hydrogels for the delivery of stem cells, growth factors, or small molecules or drugs. Despite the ability of hydrogels to enhance all these delivery methods, no material has significantly regrown vasculature within the translatable timeline of days to weeks after stroke. Here, two novel biomaterial formulations of granular hydrogels are developed for tissue regeneration after stroke: highly porous microgels (i.e., Cryo microgels) and microgels bound with heparin-norbornene nanoparticles with covalently bound SDF-1α. The combination of these materials results in perfused vessels throughout the stroke core in only 10 days, in addition to increased neural progenitor cell recruitment, maintenance, and increased neuronal differentiation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

November 2023

Start / End Page

e2302081

Related Subject Headings

  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wilson, K. L., Joseph, N. I., Onweller, L. A., Anderson, A. R., Darling, N. J., David-Bercholz, J., & Segura, T. (2023). SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke. Advanced Healthcare Materials, e2302081. https://doi.org/10.1002/adhm.202302081
Wilson, Katrina L., Neica I. Joseph, Lauren A. Onweller, Alexa R. Anderson, Nicole J. Darling, Jennifer David-Bercholz, and Tatiana Segura. “SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke.Advanced Healthcare Materials, November 2023, e2302081. https://doi.org/10.1002/adhm.202302081.
Wilson KL, Joseph NI, Onweller LA, Anderson AR, Darling NJ, David-Bercholz J, et al. SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke. Advanced healthcare materials. 2023 Nov;e2302081.
Wilson, Katrina L., et al. “SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke.Advanced Healthcare Materials, Nov. 2023, p. e2302081. Epmc, doi:10.1002/adhm.202302081.
Wilson KL, Joseph NI, Onweller LA, Anderson AR, Darling NJ, David-Bercholz J, Segura T. SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis after Stroke. Advanced healthcare materials. 2023 Nov;e2302081.
Journal cover image

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

November 2023

Start / End Page

e2302081

Related Subject Headings

  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry