Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes
Many developmental and physiological processes require cells to invade and migrate through extracellular matrix barriers. This specialized cellular behavior is also misregulated in many diseases, such as immune disorders and cancer. Cell invasive activity is driven by pro-invasive transcriptional networks that activate the expression of genes encoding numerous different proteins that expand and regulate the cytoskeleton, endomembrane system, cell adhesion, signaling pathways, and metabolic networks. While detailed mechanistic studies have uncovered crucial insights into pro-invasive transcriptional networks and the distinct cell biological attributes of invasive cells, less is known about how invasive cells modulate mRNA translation to meet the robust, dynamic, and unique protein production needs of cell invasion. In this review we outline known modes of translation regulation promoting cell invasion and focus on recent studies revealing elegant mechanisms that expand ribosome biogenesis within invasive cells to meet the increased protein production requirements to invade and migrate through extracellular matrix barriers.
Duke Scholars
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- Signal Transduction
- Ribosomes
- Proteins
- Protein Biosynthesis
- Extracellular Matrix
- 1112 Oncology and Carcinogenesis
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
Citation
DOI
Publication Date
Related Subject Headings
- Signal Transduction
- Ribosomes
- Proteins
- Protein Biosynthesis
- Extracellular Matrix
- 1112 Oncology and Carcinogenesis
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology