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A road map for the treatment of pediatric diffuse midline glioma.

Publication ,  Journal Article
Koschmann, C; Al-Holou, WN; Alonso, MM; Anastas, J; Bandopadhayay, P; Barron, T; Becher, O; Cartaxo, R; Castro, MG; Chung, C; Clausen, M ...
Published in: Cancer Cell
January 8, 2024

Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

Duke Scholars

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

January 8, 2024

Volume

42

Issue

1

Start / End Page

1 / 5

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Glioma
  • Child
  • Brain Neoplasms
  • Brain
  • Biopsy
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
 

Citation

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Koschmann, C., Al-Holou, W. N., Alonso, M. M., Anastas, J., Bandopadhayay, P., Barron, T., … Venneti, S. (2024). A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell, 42(1), 1–5. https://doi.org/10.1016/j.ccell.2023.11.002
Koschmann, Carl, Wajd N. Al-Holou, Marta M. Alonso, Jamie Anastas, Pratiti Bandopadhayay, Tara Barron, Oren Becher, et al. “A road map for the treatment of pediatric diffuse midline glioma.Cancer Cell 42, no. 1 (January 8, 2024): 1–5. https://doi.org/10.1016/j.ccell.2023.11.002.
Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, et al. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 Jan 8;42(1):1–5.
Koschmann, Carl, et al. “A road map for the treatment of pediatric diffuse midline glioma.Cancer Cell, vol. 42, no. 1, Jan. 2024, pp. 1–5. Pubmed, doi:10.1016/j.ccell.2023.11.002.
Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 Jan 8;42(1):1–5.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

January 8, 2024

Volume

42

Issue

1

Start / End Page

1 / 5

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Humans
  • Glioma
  • Child
  • Brain Neoplasms
  • Brain
  • Biopsy
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology