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Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner.

Publication ,  Journal Article
Chen, T; Wang, L; Xie, G; Kristal, BS; Zheng, X; Sun, T; Arnold, M; Louie, G; Li, M; Wu, L; Mahmoudiandehkordi, S; Sniatynski, MJ; Guo, Q ...
Published in: Adv Sci (Weinh)
March 2024

Sex disparities in serum bile acid (BA) levels and Alzheimer's disease (AD) prevalence have been established. However, the precise link between changes in serum BAs and AD development remains elusive. Here, authors quantitatively determined 33 serum BAs and 58 BA features in 4 219 samples collected from 1 180 participants from the Alzheimer's Disease Neuroimaging Initiative. The findings revealed that these BA features exhibited significant correlations with clinical stages, encompassing cognitively normal (CN), early and late mild cognitive impairment, and AD, as well as cognitive performance. Importantly, these associations are more pronounced in men than women. Among participants with progressive disease stages (n = 660), BAs underwent early changes in men, occurring before AD. By incorporating BA features into diagnostic and predictive models, positive enhancements are achieved for all models. The area under the receiver operating characteristic curve improved from 0.78 to 0.91 for men and from 0.76 to 0.83 for women for the differentiation of CN and AD. Additionally, the key findings are validated in a subset of participants (n = 578) with cerebrospinal fluid amyloid-beta and tau levels. These findings underscore the role of BAs in AD progression, offering potential improvements in the accuracy of AD prediction.

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Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

March 2024

Volume

11

Issue

9

Start / End Page

e2306576

Location

Germany

Related Subject Headings

  • Male
  • Humans
  • Female
  • Cognitive Dysfunction
  • Bile Acids and Salts
  • Amyloid beta-Peptides
  • Alzheimer Disease
 

Citation

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Chen, T., Wang, L., Xie, G., Kristal, B. S., Zheng, X., Sun, T., … Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Alzheimer Disease Metabolomics Consortium (ADMC), . (2024). Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner. Adv Sci (Weinh), 11(9), e2306576. https://doi.org/10.1002/advs.202306576
Chen, Tianlu, Lu Wang, Guoxiang Xie, Bruce S. Kristal, Xiaojiao Zheng, Tao Sun, Matthias Arnold, et al. “Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner.Adv Sci (Weinh) 11, no. 9 (March 2024): e2306576. https://doi.org/10.1002/advs.202306576.
Chen T, Wang L, Xie G, Kristal BS, Zheng X, Sun T, et al. Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner. Adv Sci (Weinh). 2024 Mar;11(9):e2306576.
Chen, Tianlu, et al. “Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner.Adv Sci (Weinh), vol. 11, no. 9, Mar. 2024, p. e2306576. Pubmed, doi:10.1002/advs.202306576.
Chen T, Wang L, Xie G, Kristal BS, Zheng X, Sun T, Arnold M, Louie G, Li M, Wu L, Mahmoudiandehkordi S, Sniatynski MJ, Borkowski K, Guo Q, Kuang J, Wang J, Nho K, Ren Z, Kueider-Paisley A, Blach C, Kaddurah-Daouk R, Jia W, Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Alzheimer Disease Metabolomics Consortium (ADMC). Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner. Adv Sci (Weinh). 2024 Mar;11(9):e2306576.
Journal cover image

Published In

Adv Sci (Weinh)

DOI

EISSN

2198-3844

Publication Date

March 2024

Volume

11

Issue

9

Start / End Page

e2306576

Location

Germany

Related Subject Headings

  • Male
  • Humans
  • Female
  • Cognitive Dysfunction
  • Bile Acids and Salts
  • Amyloid beta-Peptides
  • Alzheimer Disease