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Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth.

Publication ,  Journal Article
Vidal, AC; Sosnowski, DW; Marchesoni, J; Grenier, C; Thorp, J; Murphy, SK; Johnson, SB; Schlief, B; Hoyo, C
Published in: Epigenetics
December 2024

Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at PEG10/SGCE, NNAT, IGF2, H19, PLAGL1, PEG3, MEG3-IG, and DLK1/MEG3 regulatory sequences using pyrosequencing. Using multivariable linear regression models, we found evidence to suggest that financial stress was associated with hypermethylation of MEG3-IG in non-Hispanic White newborns; discrimination was associated with hypermethylation of IGF2 and NNAT in Hispanic newborns, and with hypomethylation of PEG3 in non-Hispanic Black newborns. We also found evidence that maternal ACEs interacted with discrimination to predict offspring PLAGL1 altered DMR methylation, in addition to interactions between maternal ACEs score and discrimination predicting H19 and SGCE/PEG10 altered methylation in non-Hispanic White newborns. However, these interactions were not statistically significant after multiple testing corrections. Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.

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Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

December 2024

Volume

19

Issue

1

Start / End Page

2293412

Location

United States

Related Subject Headings

  • RNA, Long Noncoding
  • Pregnancy
  • Infant, Newborn
  • Humans
  • Genomic Imprinting
  • Female
  • Developmental Biology
  • DNA Methylation
  • Adverse Childhood Experiences
  • 3105 Genetics
 

Citation

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Vidal, A. C., Sosnowski, D. W., Marchesoni, J., Grenier, C., Thorp, J., Murphy, S. K., … Hoyo, C. (2024). Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth. Epigenetics, 19(1), 2293412. https://doi.org/10.1080/15592294.2023.2293412
Vidal, Adriana C., David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, Billy Schlief, and Cathrine Hoyo. “Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth.Epigenetics 19, no. 1 (December 2024): 2293412. https://doi.org/10.1080/15592294.2023.2293412.
Vidal AC, Sosnowski DW, Marchesoni J, Grenier C, Thorp J, Murphy SK, et al. Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth. Epigenetics. 2024 Dec;19(1):2293412.
Vidal, Adriana C., et al. “Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth.Epigenetics, vol. 19, no. 1, Dec. 2024, p. 2293412. Pubmed, doi:10.1080/15592294.2023.2293412.
Vidal AC, Sosnowski DW, Marchesoni J, Grenier C, Thorp J, Murphy SK, Johnson SB, Schlief B, Hoyo C. Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth. Epigenetics. 2024 Dec;19(1):2293412.

Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

December 2024

Volume

19

Issue

1

Start / End Page

2293412

Location

United States

Related Subject Headings

  • RNA, Long Noncoding
  • Pregnancy
  • Infant, Newborn
  • Humans
  • Genomic Imprinting
  • Female
  • Developmental Biology
  • DNA Methylation
  • Adverse Childhood Experiences
  • 3105 Genetics