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Olfactory immunology: the missing piece in airway and CNS defence.

Publication ,  Journal Article
Wellford, SA; Moseman, EA
Published in: Nat Rev Immunol
June 2024

The olfactory mucosa is a component of the nasal airway that mediates the sense of smell. Recent studies point to an important role for the olfactory mucosa as a barrier to both respiratory pathogens and to neuroinvasive pathogens that hijack the olfactory nerve and invade the CNS. In particular, the COVID-19 pandemic has demonstrated that the olfactory mucosa is an integral part of a heterogeneous nasal mucosal barrier critical to upper airway immunity. However, our insufficient knowledge of olfactory mucosal immunity hinders attempts to protect this tissue from infection and other diseases. This Review summarizes the state of olfactory immunology by highlighting the unique immunologically relevant anatomy of the olfactory mucosa, describing what is known of olfactory immune cells, and considering the impact of common infectious diseases and inflammatory disorders at this site. We will offer our perspective on the future of the field and the many unresolved questions pertaining to olfactory immunity.

Duke Scholars

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

June 2024

Volume

24

Issue

6

Start / End Page

381 / 398

Location

England

Related Subject Headings

  • Smell
  • SARS-CoV-2
  • Olfactory Mucosa
  • Immunology
  • Immunity, Mucosal
  • Humans
  • Central Nervous System
  • COVID-19
  • Animals
  • 3204 Immunology
 

Citation

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Wellford, S. A., & Moseman, E. A. (2024). Olfactory immunology: the missing piece in airway and CNS defence. Nat Rev Immunol, 24(6), 381–398. https://doi.org/10.1038/s41577-023-00972-9
Wellford, Sebastian A., and E Ashley Moseman. “Olfactory immunology: the missing piece in airway and CNS defence.Nat Rev Immunol 24, no. 6 (June 2024): 381–98. https://doi.org/10.1038/s41577-023-00972-9.
Wellford SA, Moseman EA. Olfactory immunology: the missing piece in airway and CNS defence. Nat Rev Immunol. 2024 Jun;24(6):381–98.
Wellford, Sebastian A., and E. Ashley Moseman. “Olfactory immunology: the missing piece in airway and CNS defence.Nat Rev Immunol, vol. 24, no. 6, June 2024, pp. 381–98. Pubmed, doi:10.1038/s41577-023-00972-9.
Wellford SA, Moseman EA. Olfactory immunology: the missing piece in airway and CNS defence. Nat Rev Immunol. 2024 Jun;24(6):381–398.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

June 2024

Volume

24

Issue

6

Start / End Page

381 / 398

Location

England

Related Subject Headings

  • Smell
  • SARS-CoV-2
  • Olfactory Mucosa
  • Immunology
  • Immunity, Mucosal
  • Humans
  • Central Nervous System
  • COVID-19
  • Animals
  • 3204 Immunology