Skip to main content
Journal cover image

The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.

Publication ,  Journal Article
Clark, SL; McGinnis, EW; Zhao, M; Xie, L; Marks, GT; Aberg, KA; van den Oord, EJCG; Copeland, WE
Published in: J Am Acad Child Adolesc Psychiatry
December 27, 2023

OBJECTIVE: To test whether childhood mental health symptoms, substance use, and early adversity accelerate the rate of DNA methylation (DNAm) aging from adolescence to adulthood. METHOD: DNAm was assayed from blood samples in 381 participants in both adolescence (mean [SD] age = 13.9 [1.6] years) and adulthood (mean [SD] age = 25.9 [2.7] years). Structured diagnostic interviews were completed with participants and their parents at multiple childhood observations (1,950 total) to assess symptoms of common mental health disorders (attention-deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, anxiety, and depression) and common types of substance use (alcohol, cannabis, nicotine) and early adversities. RESULTS: Neither childhood mental health symptoms nor substance use variables were associated with DNAm aging cross-sectionally. In contrast, the following mental health symptoms and substance variables were associated with accelerated DNAm aging from adolescence to adulthood: depressive symptoms (b = 0.314, SE = 0.127, p = .014), internalizing symptoms (b = 0.108, SE = 0.049, p = .029), weekly cannabis use (b =1.665, SE = 0.591, p = .005), and years of weekly cannabis use (b = 0.718, SE = 0.283, p = .012). In models testing all individual variables simultaneously, the combined effect of the variables was equivalent to a potential difference of 3.17 to 3.76 years in DNAm aging. A final model tested a variable assessing cumulative exposure to mental health symptoms, substance use, and early adversities. This cumulative variable was strongly associated with accelerated aging (b = 0.126, SE = 0.044, p = .005). CONCLUSION: Mental health symptoms and substance use accelerated DNAm aging into adulthood in a manner consistent with a shared risk mechanism.

Duke Scholars

Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

December 27, 2023

Location

United States

Related Subject Headings

  • Developmental & Child Psychology
  • 5201 Applied and developmental psychology
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clark, S. L., McGinnis, E. W., Zhao, M., Xie, L., Marks, G. T., Aberg, K. A., … Copeland, W. E. (2023). The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood. J Am Acad Child Adolesc Psychiatry. https://doi.org/10.1016/j.jaac.2023.10.014
Clark, Shaunna L., Ellen W. McGinnis, Min Zhao, Linying Xie, Garrett T. Marks, Karolina A. Aberg, Edwin J. C. G. van den Oord, and William E. Copeland. “The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.J Am Acad Child Adolesc Psychiatry, December 27, 2023. https://doi.org/10.1016/j.jaac.2023.10.014.
Clark SL, McGinnis EW, Zhao M, Xie L, Marks GT, Aberg KA, et al. The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood. J Am Acad Child Adolesc Psychiatry. 2023 Dec 27;
Clark, Shaunna L., et al. “The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.J Am Acad Child Adolesc Psychiatry, Dec. 2023. Pubmed, doi:10.1016/j.jaac.2023.10.014.
Clark SL, McGinnis EW, Zhao M, Xie L, Marks GT, Aberg KA, van den Oord EJCG, Copeland WE. The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood. J Am Acad Child Adolesc Psychiatry. 2023 Dec 27;
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

December 27, 2023

Location

United States

Related Subject Headings

  • Developmental & Child Psychology
  • 5201 Applied and developmental psychology
  • 3213 Paediatrics
  • 3202 Clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences