Scholars@Duke

Pain management by chemogenetic control of sensory neurons.

Publication ,  Journal Article
Li, Y; Ge, X; Ji, R-R
Published in: Cell Rep Med
December 19, 2023
Published version (DOI) Link to item

In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 nicotinic acetylcholine receptor and glycine receptor pore domain via virus-mediated expression in sensory neurons, forming a chloride channel. The activation of this channel was made possible by specific agonists. This study highlights the potential for treating clinical pain by gene therapy.

Duke Scholars

Ru-Rong Ji
Author Ru-Rong Ji Anesthesiology

Published In

Cell Rep Med

DOI

10.1016/j.xcrm.2023.101338

EISSN

2666-3791

Publication Date

December 19, 2023

Volume

4

Issue

12

Start / End Page

101338

Location

United States

Related Subject Headings

  • alpha7 Nicotinic Acetylcholine Receptor
  • Sensory Receptor Cells
  • Pain Management
  • Pain
  • Mice
  • Humans
  • Animals
  • 32 Biomedical and clinical sciences
 

Citation

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Li, Y., Ge, X., & Ji, R.-R. (2023). Pain management by chemogenetic control of sensory neurons. Cell Rep Med, 4(12), 101338. https://doi.org/10.1016/j.xcrm.2023.101338
Li, Yize, Xin Ge, and Ru-Rong Ji. “Pain management by chemogenetic control of sensory neurons.” Cell Rep Med 4, no. 12 (December 19, 2023): 101338. https://doi.org/10.1016/j.xcrm.2023.101338.
Li Y, Ge X, Ji R-R. Pain management by chemogenetic control of sensory neurons. Cell Rep Med. 2023 Dec 19;4(12):101338.
Li, Yize, et al. “Pain management by chemogenetic control of sensory neurons.” Cell Rep Med, vol. 4, no. 12, Dec. 2023, p. 101338. Pubmed, doi:10.1016/j.xcrm.2023.101338.
Li Y, Ge X, Ji R-R. Pain management by chemogenetic control of sensory neurons. Cell Rep Med. 2023 Dec 19;4(12):101338.

Published In

Cell Rep Med

DOI

10.1016/j.xcrm.2023.101338

EISSN

2666-3791

Publication Date

December 19, 2023

Volume

4

Issue

12

Start / End Page

101338

Location

United States

Related Subject Headings

  • alpha7 Nicotinic Acetylcholine Receptor
  • Sensory Receptor Cells
  • Pain Management
  • Pain
  • Mice
  • Humans
  • Animals
  • 32 Biomedical and clinical sciences