Pain management by chemogenetic control of sensory neurons.
Publication
, Journal Article
Li, Y; Ge, X; Ji, R-R
Published in: Cell Rep Med
December 19, 2023
In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 nicotinic acetylcholine receptor and glycine receptor pore domain via virus-mediated expression in sensory neurons, forming a chloride channel. The activation of this channel was made possible by specific agonists. This study highlights the potential for treating clinical pain by gene therapy.
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Published In
Cell Rep Med
DOI
EISSN
2666-3791
Publication Date
December 19, 2023
Volume
4
Issue
12
Start / End Page
101338
Location
United States
Related Subject Headings
- alpha7 Nicotinic Acetylcholine Receptor
- Sensory Receptor Cells
- Pain Management
- Pain
- Mice
- Humans
- Animals
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, Y., Ge, X., & Ji, R.-R. (2023). Pain management by chemogenetic control of sensory neurons. Cell Rep Med, 4(12), 101338. https://doi.org/10.1016/j.xcrm.2023.101338
Li, Yize, Xin Ge, and Ru-Rong Ji. “Pain management by chemogenetic control of sensory neurons.” Cell Rep Med 4, no. 12 (December 19, 2023): 101338. https://doi.org/10.1016/j.xcrm.2023.101338.
Li Y, Ge X, Ji R-R. Pain management by chemogenetic control of sensory neurons. Cell Rep Med. 2023 Dec 19;4(12):101338.
Li, Yize, et al. “Pain management by chemogenetic control of sensory neurons.” Cell Rep Med, vol. 4, no. 12, Dec. 2023, p. 101338. Pubmed, doi:10.1016/j.xcrm.2023.101338.
Li Y, Ge X, Ji R-R. Pain management by chemogenetic control of sensory neurons. Cell Rep Med. 2023 Dec 19;4(12):101338.
Published In
Cell Rep Med
DOI
EISSN
2666-3791
Publication Date
December 19, 2023
Volume
4
Issue
12
Start / End Page
101338
Location
United States
Related Subject Headings
- alpha7 Nicotinic Acetylcholine Receptor
- Sensory Receptor Cells
- Pain Management
- Pain
- Mice
- Humans
- Animals
- 32 Biomedical and clinical sciences