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Advancing mouse models for transplantation research.

Publication ,  Journal Article
Cravedi, P; Riella, LV; Ford, ML; Valujskikh, A; Menon, MC; Kirk, AD; Alegre, M-L; Alessandrini, A; Feng, S; Kehn, P; Najafian, N; Hancock, WW ...
Published in: Am J Transplant
January 12, 2024

Mouse models have been instrumental in understanding mechanisms of transplant rejection and tolerance, but cross-study reproducibility and translation of experimental findings into effective clinical therapies are issues of concern. The Mouse Models in Transplantation symposium gathered scientists and physician-scientists involved in basic and clinical research in transplantation to discuss the strengths and limitations of mouse transplant models and strategies to enhance their utility. Participants recognized that increased procedure standardization, including the use of prespecified, defined endpoints, and statistical power analyses, would benefit the field. They also discussed the generation of new models that incorporate environmental and genetic variables affecting clinical outcomes as potentially important. If implemented, these strategies are expected to improve the reproducibility of mouse studies and increase their translation to clinical trials and, ideally, new Food and Drug Administration-approved drugs.

Duke Scholars

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

January 12, 2024

Location

United States

Related Subject Headings

  • Surgery
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Cravedi, P., Riella, L. V., Ford, M. L., Valujskikh, A., Menon, M. C., Kirk, A. D., … AST COTS MOuse MOdels in Transplantation (MOMOT) work group, . (2024). Advancing mouse models for transplantation research. Am J Transplant. https://doi.org/10.1016/j.ajt.2024.01.006
Cravedi, Paolo, Leonardo V. Riella, Mandy L. Ford, Anna Valujskikh, Madhav C. Menon, Allan D. Kirk, Maria-Luisa Alegre, et al. “Advancing mouse models for transplantation research.Am J Transplant, January 12, 2024. https://doi.org/10.1016/j.ajt.2024.01.006.
Cravedi P, Riella LV, Ford ML, Valujskikh A, Menon MC, Kirk AD, et al. Advancing mouse models for transplantation research. Am J Transplant. 2024 Jan 12;
Cravedi, Paolo, et al. “Advancing mouse models for transplantation research.Am J Transplant, Jan. 2024. Pubmed, doi:10.1016/j.ajt.2024.01.006.
Cravedi P, Riella LV, Ford ML, Valujskikh A, Menon MC, Kirk AD, Alegre M-L, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock WW, Heeger PS, Maltzman JS, Mannon RB, Nadig SN, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong AS, Bromberg JS, AST COTS MOuse MOdels in Transplantation (MOMOT) work group. Advancing mouse models for transplantation research. Am J Transplant. 2024 Jan 12;
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

January 12, 2024

Location

United States

Related Subject Headings

  • Surgery
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences