Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.
Publication
, Journal Article
Palmer, CD; Tomassilli, J; Sirignano, M; Romero-Tejeda, M; Arnold, KB; Che, D; Lauffenburger, DA; Jost, S; Allen, T; Mayer, KH; Altfeld, M
Published in: AIDS
September 10, 2014
This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
September 10, 2014
Volume
28
Issue
14
Start / End Page
2162 / 2166
Location
England
Related Subject Headings
- Virology
- T-Lymphocytes, Cytotoxic
- Male
- Lymphocyte Activation
- Immunity, Cellular
- Humans
- Homosexuality, Male
- HIV-1
- HIV Seronegativity
- Endotoxemia
Citation
APA
Chicago
ICMJE
MLA
NLM
Palmer, C. D., Tomassilli, J., Sirignano, M., Romero-Tejeda, M., Arnold, K. B., Che, D., … Altfeld, M. (2014). Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. AIDS, 28(14), 2162–2166. https://doi.org/10.1097/QAD.0000000000000386
Palmer, Christine D., Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B. Arnold, Denise Che, Douglas A. Lauffenburger, et al. “Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.” AIDS 28, no. 14 (September 10, 2014): 2162–66. https://doi.org/10.1097/QAD.0000000000000386.
Palmer CD, Tomassilli J, Sirignano M, Romero-Tejeda M, Arnold KB, Che D, et al. Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. AIDS. 2014 Sep 10;28(14):2162–6.
Palmer, Christine D., et al. “Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM.” AIDS, vol. 28, no. 14, Sept. 2014, pp. 2162–66. Pubmed, doi:10.1097/QAD.0000000000000386.
Palmer CD, Tomassilli J, Sirignano M, Romero-Tejeda M, Arnold KB, Che D, Lauffenburger DA, Jost S, Allen T, Mayer KH, Altfeld M. Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. AIDS. 2014 Sep 10;28(14):2162–2166.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
September 10, 2014
Volume
28
Issue
14
Start / End Page
2162 / 2166
Location
England
Related Subject Headings
- Virology
- T-Lymphocytes, Cytotoxic
- Male
- Lymphocyte Activation
- Immunity, Cellular
- Humans
- Homosexuality, Male
- HIV-1
- HIV Seronegativity
- Endotoxemia