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The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases.

Publication ,  Journal Article
Li, Z; Wang, Y; Sun, H
Published in: J Cardiovasc Transl Res
February 2024

Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for protein synthesis. Recent studies have yielded new insights into their diverse physiological and pathological roles in health and disease. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. An increasing number of clinical studies have demonstrated that high levels of circulating BCAAs are associated with an increased risk of CVDs. Animal studies have provided preliminary evidence linking BCAA intake and metabolism with cardiovascular diseases. Despite these insights, the causal relationship between BCAA metabolism and CVD remains poorly established, and the underlying mechanisms remain incompletely understood. Here, we aim to provide an update on the current understanding of the roles of BCAAs and their metabolism in the development and progression of various CVDs. We also discuss the potential strategies targeting BCAA nutrition and metabolism for the prevention and treatment of CVDs.

Duke Scholars

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

February 2024

Volume

17

Issue

1

Start / End Page

85 / 90

Location

United States

Related Subject Headings

  • Valine
  • Leucine
  • Isoleucine
  • Cardiovascular Diseases
  • Animals
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
 

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Li, Z., Wang, Y., & Sun, H. (2024). The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases. J Cardiovasc Transl Res, 17(1), 85–90. https://doi.org/10.1007/s12265-024-10479-w
Li, Zhiyu, Yibin Wang, and Haipeng Sun. “The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases.J Cardiovasc Transl Res 17, no. 1 (February 2024): 85–90. https://doi.org/10.1007/s12265-024-10479-w.
Li Z, Wang Y, Sun H. The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases. J Cardiovasc Transl Res. 2024 Feb;17(1):85–90.
Li, Zhiyu, et al. “The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases.J Cardiovasc Transl Res, vol. 17, no. 1, Feb. 2024, pp. 85–90. Pubmed, doi:10.1007/s12265-024-10479-w.
Li Z, Wang Y, Sun H. The Role of Branched-chain Amino Acids and Their Metabolism in Cardiovascular Diseases. J Cardiovasc Transl Res. 2024 Feb;17(1):85–90.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

February 2024

Volume

17

Issue

1

Start / End Page

85 / 90

Location

United States

Related Subject Headings

  • Valine
  • Leucine
  • Isoleucine
  • Cardiovascular Diseases
  • Animals
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology