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A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers.

Publication ,  Journal Article
Sanchez-Perez, JA; Berkebile, JA; Nevius, BN; Ozmen, GC; Nichols, CJ; Ganti, VG; Mabrouk, SA; Clifford, GD; Kamaleswaran, R; Wright, DW; Inan, OT
Published in: Sensors (Basel, Switzerland)
February 2022

Heart failure (HF) exacerbations, characterized by pulmonary congestion and breathlessness, require frequent hospitalizations, often resulting in poor outcomes. Current methods for tracking lung fluid and respiratory distress are unable to produce continuous, holistic measures of cardiopulmonary health. We present a multimodal sensing system that captures bioimpedance spectroscopy (BIS), multi-channel lung sounds from four contact microphones, multi-frequency impedance pneumography (IP), temperature, and kinematics to track changes in cardiopulmonary status. We first validated the system on healthy subjects (n = 10) and then conducted a feasibility study on patients (n = 14) with HF in clinical settings. Three measurements were taken throughout the course of hospitalization, and parameters relevant to lung fluid status-the ratio of the resistances at 5 kHz to those at 150 kHz (K)-and respiratory timings (e.g., respiratory rate) were extracted. We found a statistically significant increase in K (p < 0.05) from admission to discharge and observed respiratory timings in physiologically plausible ranges. The IP-derived respiratory signals and lung sounds were sensitive enough to detect abnormal respiratory patterns (Cheyne-Stokes) and inspiratory crackles from patient recordings, respectively. We demonstrated that the proposed system is suitable for detecting changes in pulmonary fluid status and capturing high-quality respiratory signals and lung sounds in a clinical setting.

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Published In

Sensors (Basel, Switzerland)

DOI

EISSN

1424-8220

ISSN

1424-8220

Publication Date

February 2022

Volume

22

Issue

3

Start / End Page

1130

Related Subject Headings

  • Wearable Electronic Devices
  • Respiratory Sounds
  • Respiratory Rate
  • Lung
  • Humans
  • Heart Failure
  • Analytical Chemistry
  • 4606 Distributed computing and systems software
  • 4104 Environmental management
  • 4009 Electronics, sensors and digital hardware
 

Citation

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Sanchez-Perez, J. A., Berkebile, J. A., Nevius, B. N., Ozmen, G. C., Nichols, C. J., Ganti, V. G., … Inan, O. T. (2022). A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers. Sensors (Basel, Switzerland), 22(3), 1130. https://doi.org/10.3390/s22031130
Sanchez-Perez, Jesus Antonio, John A. Berkebile, Brandi N. Nevius, Goktug C. Ozmen, Christopher J. Nichols, Venu G. Ganti, Samer A. Mabrouk, et al. “A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers.Sensors (Basel, Switzerland) 22, no. 3 (February 2022): 1130. https://doi.org/10.3390/s22031130.
Sanchez-Perez JA, Berkebile JA, Nevius BN, Ozmen GC, Nichols CJ, Ganti VG, et al. A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers. Sensors (Basel, Switzerland). 2022 Feb;22(3):1130.
Sanchez-Perez, Jesus Antonio, et al. “A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers.Sensors (Basel, Switzerland), vol. 22, no. 3, Feb. 2022, p. 1130. Epmc, doi:10.3390/s22031130.
Sanchez-Perez JA, Berkebile JA, Nevius BN, Ozmen GC, Nichols CJ, Ganti VG, Mabrouk SA, Clifford GD, Kamaleswaran R, Wright DW, Inan OT. A Wearable Multimodal Sensing System for Tracking Changes in Pulmonary Fluid Status, Lung Sounds, and Respiratory Markers. Sensors (Basel, Switzerland). 2022 Feb;22(3):1130.

Published In

Sensors (Basel, Switzerland)

DOI

EISSN

1424-8220

ISSN

1424-8220

Publication Date

February 2022

Volume

22

Issue

3

Start / End Page

1130

Related Subject Headings

  • Wearable Electronic Devices
  • Respiratory Sounds
  • Respiratory Rate
  • Lung
  • Humans
  • Heart Failure
  • Analytical Chemistry
  • 4606 Distributed computing and systems software
  • 4104 Environmental management
  • 4009 Electronics, sensors and digital hardware