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Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease.

Publication ,  Journal Article
Berkman, AM; Andersen, CR; Landstrom, AP; Hildebrandt, MAT; Gilchrist, SC; Roth, ME
Published in: J Adolesc Young Adult Oncol
January 23, 2024

Purpose: Childhood, adolescent, and young adult (CAYA) cancer survivors (age 0-39 years at diagnosis) are at increased risk of cardiovascular disease (CVD). Family history of early heart disease increases the risk of CVD in the general population; however, it is unknown whether this association is seen in CAYA cancer survivors. Methods: Self-report data from the National Health and Nutrition Examination Survey (2005-2018) were used to identify CAYA survivors (>5 years post-diagnosis). The risk of CVD based on family history status (parent or sibling with a diagnosis of heart attack or angina before age 50 years), personal sociodemographic factors, personal medical history factors, and personal behavioral risk factors was determined using logistic regression models. Results: Included were 95 CAYA survivors with CVD and 491 CAYA survivors without CVD. The odds of CVD were significantly higher in survivors with a first-degree family history of early heart disease (odds ratio [OR]: 2.06, 95% confidence interval [CI]: 1.14-3.74). A history of diabetes (OR: 2.61, 95% CI: 1.41-4.84), hypertension (OR: 1.81, 95% CI: 1.04-3.16), and any smoking (OR: 2.19, 95% CI: 1.19-4.02) was also associated with higher odds of CVD in CAYA survivors. Reporting any physical activity in the past month was associated with lower odds (OR: 0.54, 95% CI: 0.30-0.97) of CVD. Conclusions: Family history of early heart disease was associated with increased odds of CVD in CAYA cancer survivors. Obtaining complete and accurate family history information is important both at time of diagnosis and throughout follow-up.

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Published In

J Adolesc Young Adult Oncol

DOI

EISSN

2156-535X

Publication Date

January 23, 2024

Location

United States

Related Subject Headings

  • 4205 Nursing
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
  • 1110 Nursing
 

Citation

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Berkman, A. M., Andersen, C. R., Landstrom, A. P., Hildebrandt, M. A. T., Gilchrist, S. C., & Roth, M. E. (2024). Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease. J Adolesc Young Adult Oncol. https://doi.org/10.1089/jayao.2023.0130
Berkman, Amy M., Clark R. Andersen, Andrew P. Landstrom, Michelle A. T. Hildebrandt, Susan C. Gilchrist, and Michael E. Roth. “Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease.J Adolesc Young Adult Oncol, January 23, 2024. https://doi.org/10.1089/jayao.2023.0130.
Berkman AM, Andersen CR, Landstrom AP, Hildebrandt MAT, Gilchrist SC, Roth ME. Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease. J Adolesc Young Adult Oncol. 2024 Jan 23;
Berkman, Amy M., et al. “Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease.J Adolesc Young Adult Oncol, Jan. 2024. Pubmed, doi:10.1089/jayao.2023.0130.
Berkman AM, Andersen CR, Landstrom AP, Hildebrandt MAT, Gilchrist SC, Roth ME. Cardiovascular Disease in Childhood, Adolescent, and Young Adult Cancer Survivors: The Impact of Family History of Premature Heart Disease. J Adolesc Young Adult Oncol. 2024 Jan 23;
Journal cover image

Published In

J Adolesc Young Adult Oncol

DOI

EISSN

2156-535X

Publication Date

January 23, 2024

Location

United States

Related Subject Headings

  • 4205 Nursing
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
  • 1110 Nursing