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Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study.

Publication ,  Journal Article
Ghany, MG; Belle, SH; Kleiner, DE; Smith, C; Kelley, SS; Rosenthal, P; Fontana, RJ; Hepatitis B Research Network
Published in: Hepatol Commun
June 1, 2023

BACKGROUND: Prospective data regarding the safety and yield of liver biopsy in both adults and children with chronic hepatitis B are limited. The aim of this study is to report safety, yield, and complication rates among adults and children with chronic hepatitis B undergoing percutaneous liver biopsy. METHODS: Data on the indication for procedural characteristics and complication rate for liver biopsies performed as part of the Hepatitis B Research Network were prospectively recorded on a study case report form and analyzed in aggregate. RESULTS: Among 2506 adult and pediatric subjects enrolled in the Hepatitis B Research Network between 2011 and 2018, 465 (19%) underwent 491 liver biopsies for clinical or research reasons. Adequate liver tissue was obtained in 98% of the procedures. In total, there were 32 complications reported for 24 biopsies: 23 biopsies with 30 complications in adults and 1 biopsy with 2 complications in children. Pain (n=19) and vasovagal reaction (n=6) were the most common complications. There were 7 serious adverse events, including an arterioportal venous fistula, a pneumothorax, 4 cases of bleeding, and severe pain with no associated condition. There were no deaths. CONCLUSIONS: These data demonstrate that percutaneous liver biopsy is associated with a high yield of tissue (98%) and a rate of serious complications of 1.4% in both children and adults with chronic HBV. These results support the focused use of liver biopsy in the evaluation of novel treatments in development for chronic hepatitis B.

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Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

June 1, 2023

Volume

7

Issue

6

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pain
  • Humans
  • Hepatitis B, Chronic
  • Child
  • Biopsy
  • Adult
  • 3202 Clinical sciences
 

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Ghany, M. G., Belle, S. H., Kleiner, D. E., Smith, C., Kelley, S. S., Rosenthal, P., … Hepatitis B Research Network. (2023). Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. Hepatol Commun, 7(6). https://doi.org/10.1097/HC9.0000000000000116
Ghany, Marc G., Steven H. Belle, David E. Kleiner, Coleman Smith, Stephanie S. Kelley, Philip Rosenthal, Robert J. Fontana, and Hepatitis B Research Network. “Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study.Hepatol Commun 7, no. 6 (June 1, 2023). https://doi.org/10.1097/HC9.0000000000000116.
Ghany MG, Belle SH, Kleiner DE, Smith C, Kelley SS, Rosenthal P, et al. Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. Hepatol Commun. 2023 Jun 1;7(6).
Ghany, Marc G., et al. “Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study.Hepatol Commun, vol. 7, no. 6, June 2023. Pubmed, doi:10.1097/HC9.0000000000000116.
Ghany MG, Belle SH, Kleiner DE, Smith C, Kelley SS, Rosenthal P, Fontana RJ, Hepatitis B Research Network. Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. Hepatol Commun. 2023 Jun 1;7(6).

Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

June 1, 2023

Volume

7

Issue

6

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pain
  • Humans
  • Hepatitis B, Chronic
  • Child
  • Biopsy
  • Adult
  • 3202 Clinical sciences