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Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.

Publication ,  Journal Article
Potosky, AL; Ahn, J; Xia, Y; Lin, L; Chen, RC; Graves, KD; Pan, W; Fall-Dickson, JM; Keegan, THM; Paddock, LE; Wu, X-C; Shrestha, A; Reeve, BB
Published in: JCO Oncol Pract
July 2024

PURPOSE: Our purpose was to describe the prevalence and predictors of symptom and function clusters related to physical, emotional, and social components of general health-related quality of life (HRQOL) in a population-based sample of prostate cancer (PCa) survivors. METHODS: Participants (N = 1,162) completed a baseline survey at a median of 9 months after diagnosis to ascertain the co-occurrence of eight symptom and functional domains that are common across all cancers and not treatment-specific. We used latent profile analysis (LPA) to identify subgroup profiles of survivors with low, moderate, or high HRQOL levels. Multinomial logistic regression models were used to identify clinical and sociodemographic factors associated with survivors' membership in the low versus moderate or high HRQOL profile. RESULTS: The LPA identified 16% of survivors who were categorized in the low HRQOL profile at baseline, indicative of the highest symptom burden and lowest functioning. Factors related to survivors' membership in the low versus higher HRQOL profile groups included less than age 65 years at diagnosis, identifying as non-Hispanic Black race, not working, being a former versus never smoker, systemic therapy, less companionship, more comorbidities, lower health care financial well-being, or less spirituality. Several factors remained associated with remaining in the low versus higher HRQOL profiles on the follow-up survey (n = 699), including younger age, Black race, comorbidity, and lower financial and spiritual well-being. CONCLUSION: About one of six PCa survivors experienced elevated physical and psychosocial symptoms that were independent of local curative therapy, but with younger age, race, comorbidity, and lower financial and spiritual well-being as stable risk factors for poor HRQOL over time.

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Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

July 2024

Volume

20

Issue

7

Start / End Page

921 / 931

Location

United States

Related Subject Headings

  • Quality of Life
  • Prostatic Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Cancer Survivors
  • Aged
  • 3211 Oncology and carcinogenesis
 

Citation

APA
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Potosky, A. L., Ahn, J., Xia, Y., Lin, L., Chen, R. C., Graves, K. D., … Reeve, B. B. (2024). Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract, 20(7), 921–931. https://doi.org/10.1200/OP.24.00076
Potosky, Arnold L., Jaeil Ahn, Yi Xia, Li Lin, Ronald C. Chen, Kristi D. Graves, Wei Pan, et al. “Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.JCO Oncol Pract 20, no. 7 (July 2024): 921–31. https://doi.org/10.1200/OP.24.00076.
Potosky AL, Ahn J, Xia Y, Lin L, Chen RC, Graves KD, et al. Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract. 2024 Jul;20(7):921–31.
Potosky, Arnold L., et al. “Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.JCO Oncol Pract, vol. 20, no. 7, July 2024, pp. 921–31. Pubmed, doi:10.1200/OP.24.00076.
Potosky AL, Ahn J, Xia Y, Lin L, Chen RC, Graves KD, Pan W, Fall-Dickson JM, Keegan THM, Paddock LE, Wu X-C, Shrestha A, Reeve BB. Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract. 2024 Jul;20(7):921–931.

Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

July 2024

Volume

20

Issue

7

Start / End Page

921 / 931

Location

United States

Related Subject Headings

  • Quality of Life
  • Prostatic Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Cancer Survivors
  • Aged
  • 3211 Oncology and carcinogenesis