Skip to main content

Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.

Publication ,  Journal Article
Potosky, AL; Ahn, J; Xia, Y; Lin, L; Chen, RC; Graves, KD; Pan, W; Fall-Dickson, JM; Keegan, THM; Paddock, LE; Wu, X-C; Shrestha, A; Reeve, BB
Published in: JCO Oncol Pract
March 11, 2024

PURPOSE: Our purpose was to describe the prevalence and predictors of symptom and function clusters related to physical, emotional, and social components of general health-related quality of life (HRQOL) in a population-based sample of prostate cancer (PCa) survivors. METHODS: Participants (N = 1,162) completed a baseline survey at a median of 9 months after diagnosis to ascertain the co-occurrence of eight symptom and functional domains that are common across all cancers and not treatment-specific. We used latent profile analysis (LPA) to identify subgroup profiles of survivors with low, moderate, or high HRQOL levels. Multinomial logistic regression models were used to identify clinical and sociodemographic factors associated with survivors' membership in the low versus moderate or high HRQOL profile. RESULTS: The LPA identified 16% of survivors who were categorized in the low HRQOL profile at baseline, indicative of the highest symptom burden and lowest functioning. Factors related to survivors' membership in the low versus higher HRQOL profile groups included less than age 65 years at diagnosis, identifying as non-Hispanic Black race, not working, being a former versus never smoker, systemic therapy, less companionship, more comorbidities, lower health care financial well-being, or less spirituality. Several factors remained associated with remaining in the low versus higher HRQOL profiles on the follow-up survey (n = 699), including younger age, Black race, comorbidity, and lower financial and spiritual well-being. CONCLUSION: About one of six PCa survivors experienced elevated physical and psychosocial symptoms that were independent of local curative therapy, but with younger age, race, comorbidity, and lower financial and spiritual well-being as stable risk factors for poor HRQOL over time.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

March 11, 2024

Start / End Page

OP2400076

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Potosky, A. L., Ahn, J., Xia, Y., Lin, L., Chen, R. C., Graves, K. D., … Reeve, B. B. (2024). Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract, OP2400076. https://doi.org/10.1200/OP.24.00076
Potosky, Arnold L., Jaeil Ahn, Yi Xia, Li Lin, Ronald C. Chen, Kristi D. Graves, Wei Pan, et al. “Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.JCO Oncol Pract, March 11, 2024, OP2400076. https://doi.org/10.1200/OP.24.00076.
Potosky AL, Ahn J, Xia Y, Lin L, Chen RC, Graves KD, et al. Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract. 2024 Mar 11;OP2400076.
Potosky, Arnold L., et al. “Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.JCO Oncol Pract, Mar. 2024, p. OP2400076. Pubmed, doi:10.1200/OP.24.00076.
Potosky AL, Ahn J, Xia Y, Lin L, Chen RC, Graves KD, Pan W, Fall-Dickson JM, Keegan THM, Paddock LE, Wu X-C, Shrestha A, Reeve BB. Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors. JCO Oncol Pract. 2024 Mar 11;OP2400076.

Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

March 11, 2024

Start / End Page

OP2400076

Location

United States

Related Subject Headings

  • 3211 Oncology and carcinogenesis