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How should a cluster randomized trial be analyzed?

Publication ,  Journal Article
Billot, L; Copas, A; Leyrat, C; Forbes, A; Turner, EL
Published in: J Epidemiol Popul Health
February 2024

In cluster randomized trials, individuals from the same cluster tend to have more similar outcomes than individuals from different clusters. This correlation must be taken into account in the analysis of every cluster trial to avoid incorrect inferences. In this paper, we describe the principles guiding the analysis of cluster trials including how to correctly account for intra-cluster correlations as well as how to analyze more advanced designs such as stepped-wedge and cluster cross-over trials. We then describe how to handle specific issues such as small sample sizes and missing data.

Duke Scholars

Published In

J Epidemiol Popul Health

DOI

EISSN

2950-4333

Publication Date

February 2024

Volume

72

Issue

1

Start / End Page

202196

Location

France

Related Subject Headings

  • Sample Size
  • Research Design
  • Randomized Controlled Trials as Topic
  • Humans
  • Cross-Over Studies
  • Cluster Analysis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Billot, L., Copas, A., Leyrat, C., Forbes, A., & Turner, E. L. (2024). How should a cluster randomized trial be analyzed? J Epidemiol Popul Health, 72(1), 202196. https://doi.org/10.1016/j.jeph.2024.202196
Billot, Laurent, Andrew Copas, Clemence Leyrat, Andrew Forbes, and Elizabeth L. Turner. “How should a cluster randomized trial be analyzed?J Epidemiol Popul Health 72, no. 1 (February 2024): 202196. https://doi.org/10.1016/j.jeph.2024.202196.
Billot L, Copas A, Leyrat C, Forbes A, Turner EL. How should a cluster randomized trial be analyzed? J Epidemiol Popul Health. 2024 Feb;72(1):202196.
Billot, Laurent, et al. “How should a cluster randomized trial be analyzed?J Epidemiol Popul Health, vol. 72, no. 1, Feb. 2024, p. 202196. Pubmed, doi:10.1016/j.jeph.2024.202196.
Billot L, Copas A, Leyrat C, Forbes A, Turner EL. How should a cluster randomized trial be analyzed? J Epidemiol Popul Health. 2024 Feb;72(1):202196.

Published In

J Epidemiol Popul Health

DOI

EISSN

2950-4333

Publication Date

February 2024

Volume

72

Issue

1

Start / End Page

202196

Location

France

Related Subject Headings

  • Sample Size
  • Research Design
  • Randomized Controlled Trials as Topic
  • Humans
  • Cross-Over Studies
  • Cluster Analysis