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Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations.

Publication ,  Journal Article
Huang, C-Y; Jiang, N; Shen, M; Lai, GG; Tan, AC; Jain, A; Saw, SP; Ang, MK; Ng, QS; Lim, DW; Kanesvaran, R; Tan, EH; Tan, WL; Ong, B-H ...
Published in: Cancer Res
April 8, 2024

Non-small cell lung cancers (NSCLCs) in non-smokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET and fusions involving ALK and RET. In addition to occurring in non-smokers, alterations in these "non-smoking-related oncogenes" (NSROs) also occur in smokers. To better understand the clonal architecture and genomic landscape of NSRO-driven tumors in smokers compared to typical-smoking NSCLCs, we investigated genomic and transcriptomic alterations in 173 tumor sectors from 48 NSCLC patients. NSRO-driven NSCLCs in smokers and non-smokers had similar genomic landscapes. Surprisingly, even in patients with prominent smoking histories, the mutational signature caused by tobacco smoking was essentially absent in NSRO-driven NSCLCs, which was confirmed in two large NSCLC datasets from other geographic regions. However, NSRO-driven NSCLCs in smokers had higher transcriptomic activities related to regulation of the cell cycle. These findings suggest that, while the genomic landscape is similar between NSRO-driven NSCLC in smokers and non-smokers, smoking still affects the tumor phenotype independently of genomic alterations.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

April 8, 2024

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

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Huang, C.-Y., Jiang, N., Shen, M., Lai, G. G., Tan, A. C., Jain, A., … Rozen, S. G. (2024). Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-23-2551
Huang, Chen-Yang, Nanhai Jiang, Meixin Shen, Gillianne G. Lai, Aaron C. Tan, Amit Jain, Stephanie P. Saw, et al. “Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations.Cancer Res, April 8, 2024. https://doi.org/10.1158/0008-5472.CAN-23-2551.
Huang C-Y, Jiang N, Shen M, Lai GG, Tan AC, Jain A, et al. Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations. Cancer Res. 2024 Apr 8;
Huang, Chen-Yang, et al. “Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations.Cancer Res, Apr. 2024. Pubmed, doi:10.1158/0008-5472.CAN-23-2551.
Huang C-Y, Jiang N, Shen M, Lai GG, Tan AC, Jain A, Saw SP, Ang MK, Ng QS, Lim DW, Kanesvaran R, Tan EH, Tan WL, Ong B-H, Chua KL, Anantham D, Takano AM, Lim KH, Tam WL, Sim NL, Skanderup AJ, Tan DS, Rozen SG. Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations. Cancer Res. 2024 Apr 8;

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

April 8, 2024

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis