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Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV.

Publication ,  Journal Article
Kardashian, A; Lloyd, A; Vilar-Gomez, E; Naggie, S; Sulkowski, MS; Woreta, T; Lake, JE; Crandall, H; Loomba, R; Wilson, LA; Sterling, RK ...
Published in: Clin Gastroenterol Hepatol
April 5, 2024

BACKGROUND & AIMS: Food insecurity (FI) is a risk factor for nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis in the general population, but its impact on liver disease in people with HIV (PWH) is unknown. METHODS: We examined the association of FI with prevalence of NAFLD and fibrosis in a diverse cohort of PWH. PWH aged ≥ 18 years on antiretroviral therapy, HIV RNA <200 copies/mL, and without other known liver diseases were screened for NAFLD (controlled attenuated parameter ≥263 decibels/meter) and advanced fibrosis (liver stiffness measurement ≥11 kilopascals) by vibration controlled transient elastography at 8 U.S. CENTERS: Participants were categorized as food insecure using the Six-Item Short Form Household Food Security Survey. We used multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of NAFLD and advanced fibrosis by FI status. RESULTS: Among 654 PWH, NAFLD was present in 348 (53%) and advanced fibrosis in 41 (6%). FI was present in 203 of participants (31%), including 97/348 with NAFLD (28%) and 18/41 with advanced fibrosis (44%). In multivariable analysis, FI was associated with lower odds of NAFLD (OR, 0.57; 95% CI, 0.37-0.88) and a greater, but nonsignificant, odds of advanced fibrosis (OR, 1.38; 95% CI, 0.65-2.90). We identified a significant interaction between FI and diabetes (P = .02) on fibrosis risk, with greater odds of fibrosis among food insecure PWH and diabetes (OR, 3.83; 95% CI, 1.15-12.73) but not among food insecure nondiabetics (OR, 1.12; 95% CI, 0.47-2.98). CONCLUSIONS: FI is highly prevalent among PWH and associated with lower odds of NAFLD, and among PWH with diabetes, there is greater odds of advanced fibrosis. FI may contribute to hepatic fibrosis through mechanisms other than steatosis in PWH.

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Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

April 5, 2024

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

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Kardashian, A., Lloyd, A., Vilar-Gomez, E., Naggie, S., Sulkowski, M. S., Woreta, T., … HIV NASH Clinical Research Network, . (2024). Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV. Clin Gastroenterol Hepatol. https://doi.org/10.1016/j.cgh.2024.03.017
Kardashian, Ani, Audrey Lloyd, Eduardo Vilar-Gomez, Susanna Naggie, Mark S. Sulkowski, Tinsay Woreta, Jordan E. Lake, et al. “Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV.Clin Gastroenterol Hepatol, April 5, 2024. https://doi.org/10.1016/j.cgh.2024.03.017.
Kardashian A, Lloyd A, Vilar-Gomez E, Naggie S, Sulkowski MS, Woreta T, et al. Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV. Clin Gastroenterol Hepatol. 2024 Apr 5;
Kardashian, Ani, et al. “Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV.Clin Gastroenterol Hepatol, Apr. 2024. Pubmed, doi:10.1016/j.cgh.2024.03.017.
Kardashian A, Lloyd A, Vilar-Gomez E, Naggie S, Sulkowski MS, Woreta T, Lake JE, Crandall H, Loomba R, Wilson LA, Sterling RK, Heath S, Gawrieh S, Chalasani NP, Price JC, HIV NASH Clinical Research Network. Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV. Clin Gastroenterol Hepatol. 2024 Apr 5;
Journal cover image

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

April 5, 2024

Location

United States

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences