Individualized interventions and precision health: Lessons learned from a systematic review and implications for analytics-driven geriatric research.
Older adults are characterized by profound clinical heterogeneity. When designing and delivering interventions, there exist multiple approaches to account for heterogeneity. We present the results of a systematic review of data-driven, personalized interventions in older adults, which serves as a use case to distinguish the conceptual and methodologic differences between individualized intervention delivery and precision health-derived interventions. We define individualized interventions as those where all participants received the same parent intervention, modified on a case-by-case basis and using an evidence-based protocol, supplemented by clinical judgment as appropriate, while precision health-derived interventions are those that tailor care to individuals whereby the strategy for how to tailor care was determined through data-driven, precision health analytics. We discuss how their integration may offer new opportunities for analytics-based geriatric medicine that accommodates individual heterogeneity but allows for more flexible and resource-efficient population-level scaling.
Duke Scholars
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Related Subject Headings
- Precision Medicine
- Humans
- Geriatrics
- Geriatrics
- Aged
- 52 Psychology
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Precision Medicine
- Humans
- Geriatrics
- Geriatrics
- Aged
- 52 Psychology
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences