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What facets of physical function are most important to adults diagnosed with cancer?

Publication ,  Journal Article
Coles, T; Plyler, K; Hernandez, A; Fillipo, R; Henke, DM; Arizmendi, C; Lagoo-Deenadayalan, S; Goodwin, CR; LeBlanc, TW; Horodniceanu, EG ...
Published in: Qual Life Res
April 20, 2024

PURPOSE: Successful patient-focused drug development involves selecting and measuring outcomes in clinical trials that are important to patients. The U.S. Food & Drug Administration's definition of clinical benefit includes how patients feel, function, or survive. Patients are considered the experts in describing how they feel and function. In cancer trials, patient-reported measures of physical function provide insight into how patients function at baseline, benefit from the interventions being studied, and the impact of treatment side effects. We conducted a qualitative study with adults diagnosed with cancer to describe facets of physical function from their perspective and to identify which facets are most important to this patient population. METHODS: Using concept elicitation and cognitive interviewing techniques, we conducted semi-structured interviews with 72 adults ≥ 22 years of age with cancer who received treatment with an anticancer drug or biologic within six months of the interview. We selected participants using purposive sampling with the aim to elicit diverse experiences regarding how they may interpret and respond to questions related to physical function. Participants were presented with patient-reported outcome (PRO) items representative of PRO measures used in cancer and general populations. RESULTS: Five facets of how physical function relates to activities were defined from the patient perspective: ability, difficulty, limitation, satisfaction, and completion. More than half of the participants indicated that ability was the most important facet of physical function. The next most important were satisfaction (18.3%), limitation (14.1%), difficulty (5.6%), and completion (2.8%). CONCLUSION: This study demonstrates that we must be more specific about the facets of physical function that we set out to assess when we use PRO measures to describe the patient experience. These results have implications for the specificity of physical function facets when measured in cancer clinical trials.

Duke Scholars

Published In

Qual Life Res

DOI

EISSN

1573-2649

Publication Date

April 20, 2024

Location

Netherlands

Related Subject Headings

  • Health Policy & Services
  • 44 Human society
  • 42 Health sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

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Coles, T., Plyler, K., Hernandez, A., Fillipo, R., Henke, D. M., Arizmendi, C., … Weinfurt, K. P. (2024). What facets of physical function are most important to adults diagnosed with cancer? Qual Life Res. https://doi.org/10.1007/s11136-024-03654-8
Coles, Theresa, Kate Plyler, Alexy Hernandez, Rebecca Fillipo, Debra M. Henke, Cara Arizmendi, Sandhya Lagoo-Deenadayalan, et al. “What facets of physical function are most important to adults diagnosed with cancer?Qual Life Res, April 20, 2024. https://doi.org/10.1007/s11136-024-03654-8.
Coles T, Plyler K, Hernandez A, Fillipo R, Henke DM, Arizmendi C, et al. What facets of physical function are most important to adults diagnosed with cancer? Qual Life Res. 2024 Apr 20;
Coles, Theresa, et al. “What facets of physical function are most important to adults diagnosed with cancer?Qual Life Res, Apr. 2024. Pubmed, doi:10.1007/s11136-024-03654-8.
Coles T, Plyler K, Hernandez A, Fillipo R, Henke DM, Arizmendi C, Lagoo-Deenadayalan S, Goodwin CR, LeBlanc TW, Horodniceanu EG, Bhatnagar V, Reeve BB, Weinfurt KP. What facets of physical function are most important to adults diagnosed with cancer? Qual Life Res. 2024 Apr 20;
Journal cover image

Published In

Qual Life Res

DOI

EISSN

1573-2649

Publication Date

April 20, 2024

Location

Netherlands

Related Subject Headings

  • Health Policy & Services
  • 44 Human society
  • 42 Health sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services