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Influence of substance use on male reproductive health and offspring outcomes.

Publication ,  Journal Article
Lo, JO; Hedges, JC; Chou, WH; Tager, KR; Bachli, ID; Hagen, OL; Murphy, SK; Hanna, CB; Easley, CA
Published in: Nat Rev Urol
April 25, 2024

The prevalence of substance use globally is rising and is highest among men of reproductive age. In Africa, and South and Central America, cannabis use disorder is most prevalent and in Eastern and South-Eastern Europe, Central America, Canada and the USA, opioid use disorder predominates. Substance use might be contributing to the ongoing global decline in male fertility, and emerging evidence has linked paternal substance use with short-term and long-term adverse effects on offspring development and outcomes. This trend is concerning given that substance use is increasing, including during the COVID-19 pandemic. Preclinical studies have shown that male preconception substance use can influence offspring brain development and neurobehaviour through epigenetic mechanisms. Additionally, human studies investigating paternal health behaviours during the prenatal period suggest that paternal tobacco, opioid, cannabis and alcohol use is associated with reduced offspring mental health, in particular hyperactivity and attention-deficit hyperactivity disorder. The potential effects of paternal substance use are areas in which to focus public health efforts and health-care provider counselling of couples or individuals interested in conceiving.

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Published In

Nat Rev Urol

DOI

EISSN

1759-4820

Publication Date

April 25, 2024

Location

England

Related Subject Headings

  • Urology & Nephrology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Lo, J. O., Hedges, J. C., Chou, W. H., Tager, K. R., Bachli, I. D., Hagen, O. L., … Easley, C. A. (2024). Influence of substance use on male reproductive health and offspring outcomes. Nat Rev Urol. https://doi.org/10.1038/s41585-024-00868-w
Lo, Jamie O., Jason C. Hedges, Wesley H. Chou, Kylie R. Tager, Ian D. Bachli, Olivia L. Hagen, Susan K. Murphy, Carol B. Hanna, and Charles A. Easley. “Influence of substance use on male reproductive health and offspring outcomes.Nat Rev Urol, April 25, 2024. https://doi.org/10.1038/s41585-024-00868-w.
Lo JO, Hedges JC, Chou WH, Tager KR, Bachli ID, Hagen OL, et al. Influence of substance use on male reproductive health and offspring outcomes. Nat Rev Urol. 2024 Apr 25;
Lo, Jamie O., et al. “Influence of substance use on male reproductive health and offspring outcomes.Nat Rev Urol, Apr. 2024. Pubmed, doi:10.1038/s41585-024-00868-w.
Lo JO, Hedges JC, Chou WH, Tager KR, Bachli ID, Hagen OL, Murphy SK, Hanna CB, Easley CA. Influence of substance use on male reproductive health and offspring outcomes. Nat Rev Urol. 2024 Apr 25;

Published In

Nat Rev Urol

DOI

EISSN

1759-4820

Publication Date

April 25, 2024

Location

England

Related Subject Headings

  • Urology & Nephrology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences