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Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia.

Publication ,  Journal Article
Babushok, DV; DeZern, AE; de Castro, C; Rogers, ZR; Beenhouwer, D; Broder, MS; Fanning, S; Gibbs, SN; Hanna, R; Maciejewski, JP; Scott, BL ...
Published in: Blood Adv
April 26, 2024

Severe aplastic anemia (SAA) is a rare hematologic condition for which there is no clear management algorithm. A panel of 11 adult and pediatric experts on aplastic anemia was assembled and, using the RAND/UCLA modified Delphi panel method, evaluated >600 varying patient care scenarios to develop clinical recommendations for the initial and subsequent management of patients of all ages with SAA. Here we present the panel's recommendations to rule out inherited bone marrow failure (IBMF) syndromes, on supportive care prior to and during first-line therapy, and on first-line (initial management) and second-line (subsequent management) therapy of acquired SAA, focusing on when transplant versus medical therapy is most appropriate. These recommendations represent the consensus of 11 experts informed by published literature and experience. They are intended only as general guidance for experienced clinicians who treat patients with SAA and are in no way intended to supersede individual physician and patient decision-making. Current and future research should validate this consensus using clinical data. Once validated, we hope these expert panel recommendations will improve outcomes for patients with SAA.

Duke Scholars

Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

April 26, 2024

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
 

Citation

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Babushok, D. V., DeZern, A. E., de Castro, C., Rogers, Z. R., Beenhouwer, D., Broder, M. S., … Patel, B. J. (2024). Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia. Blood Adv. https://doi.org/10.1182/bloodadvances.2023011642
Babushok, Daria V., Amy E. DeZern, Carlos de Castro, Zora R. Rogers, David Beenhouwer, Michael S. Broder, Suzanne Fanning, et al. “Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia.Blood Adv, April 26, 2024. https://doi.org/10.1182/bloodadvances.2023011642.
Babushok DV, DeZern AE, de Castro C, Rogers ZR, Beenhouwer D, Broder MS, et al. Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia. Blood Adv. 2024 Apr 26;
Babushok, Daria V., et al. “Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia.Blood Adv, Apr. 2024. Pubmed, doi:10.1182/bloodadvances.2023011642.
Babushok DV, DeZern AE, de Castro C, Rogers ZR, Beenhouwer D, Broder MS, Fanning S, Gibbs SN, Hanna R, Maciejewski JP, Scott BL, Tantravahi SK, Wlodarski MW, Yermilov I, Patel BJ. Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia. Blood Adv. 2024 Apr 26;

Published In

Blood Adv

DOI

EISSN

2473-9537

Publication Date

April 26, 2024

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology