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Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen

Publication ,  Journal Article
Falah, B; Kotinkaduwa, LN; Schonning, MJ; Redfors, B; de Waha, S; Granger, CB; Maehara, A; Eitel, I; Thiele, H; Stone, GW
Published in: Journal of the Society for Cardiovascular Angiography and Interventions
May 1, 2024

Background: Supersaturated oxygen (SSO2) delivered into the left anterior descending coronary artery after percutaneous coronary intervention (PCI) for anterior ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size, but its effects on microvascular obstruction (MVO) are unknown. The aim of this study was to compare MVO in patients with anterior STEMI treated with SSO2 after successful primary PCI from 2 studies (the optimized SSO2 pilot and IC-HOT) with similar patients from 7 randomized trials who underwent primary PCI without SSO2 treatment. Methods: A total of 874 patients with anterior STEMI who underwent MVO assessment using cardiac magnetic resonance imaging within 10 days after primary PCI were included, of whom 90 patients (10.3%) were treated with SSO2. The primary end point was the extent of MVO as a continuous measure in a weighted multivariable model. The secondary end point was the presence of MVO. Results: SSO2 therapy was independently associated with a lower extent of MVO compared with no SSO2 therapy (coefficient, −1.35; 95% CI, −2.58 to −0.11; P = .03). SSO2 therapy was also associated with a borderline lower risk of any MVO (adjusted odds ratio, 0.56; 95% CI, 0.31-1.00; P = .051). Conclusions: In the present individual patient data pooled analysis from 9 studies, SSO2 therapy was associated with less MVO after successful primary PCI for anterior STEMI.

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Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

May 1, 2024

Volume

3

Issue

5
 

Citation

APA
Chicago
ICMJE
MLA
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Falah, B., Kotinkaduwa, L. N., Schonning, M. J., Redfors, B., de Waha, S., Granger, C. B., … Stone, G. W. (2024). Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen. Journal of the Society for Cardiovascular Angiography and Interventions, 3(5). https://doi.org/10.1016/j.jscai.2024.101356
Falah, B., L. N. Kotinkaduwa, M. J. Schonning, B. Redfors, S. de Waha, C. B. Granger, A. Maehara, I. Eitel, H. Thiele, and G. W. Stone. “Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen.” Journal of the Society for Cardiovascular Angiography and Interventions 3, no. 5 (May 1, 2024). https://doi.org/10.1016/j.jscai.2024.101356.
Falah B, Kotinkaduwa LN, Schonning MJ, Redfors B, de Waha S, Granger CB, et al. Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen. Journal of the Society for Cardiovascular Angiography and Interventions. 2024 May 1;3(5).
Falah, B., et al. “Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen.” Journal of the Society for Cardiovascular Angiography and Interventions, vol. 3, no. 5, May 2024. Scopus, doi:10.1016/j.jscai.2024.101356.
Falah B, Kotinkaduwa LN, Schonning MJ, Redfors B, de Waha S, Granger CB, Maehara A, Eitel I, Thiele H, Stone GW. Microvascular Obstruction in Patients With Anterior STEMI Treated With Supersaturated Oxygen. Journal of the Society for Cardiovascular Angiography and Interventions. 2024 May 1;3(5).

Published In

Journal of the Society for Cardiovascular Angiography and Interventions

DOI

EISSN

2772-9303

Publication Date

May 1, 2024

Volume

3

Issue

5