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Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis.

Publication ,  Journal Article
Richmond-Rakerd, LS; Iyer, MT; D'Souza, S; Khalifeh, L; Caspi, A; Moffitt, TE; Milne, BJ
Published in: Nature aging
June 2024

Infections, which can prompt neuroinflammation, may be a risk factor for dementia1-5. More information is needed concerning associations across different infections and different dementias, and from longitudinal studies with long follow-ups. This New Zealand-based population register study tested whether infections antedate dementia across three decades. We identified individuals born between 1929 and 1968 and followed them from 1989 to 2019 (n = 1,742,406, baseline age = 21-60 years). Infection diagnoses were ascertained from public hospital records. Dementia diagnoses were ascertained from public hospital, mortality and pharmaceutical records. Relative to individuals without an infection, those with an infection were at increased risk of dementia (hazard ratio 2.93, 95% confidence interval 2.68-3.20). Associations were evident for dementia diagnoses made up to 25-30 years after infection diagnoses. Associations held after accounting for preexisting physical diseases, mental disorders and socioeconomic deprivation. Associations were evident for viral, bacterial, parasitic and other infections, and for Alzheimer's disease and other dementias, including vascular dementia. Preventing infections might reduce the burden of neurodegenerative conditions.

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Published In

Nature aging

DOI

EISSN

2662-8465

ISSN

2662-8465

Publication Date

June 2024

Volume

4

Issue

6

Start / End Page

783 / 790

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Registries
  • New Zealand
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Infections
  • Humans
  • Hospitalization
 

Citation

APA
Chicago
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MLA
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Richmond-Rakerd, L. S., Iyer, M. T., D’Souza, S., Khalifeh, L., Caspi, A., Moffitt, T. E., & Milne, B. J. (2024). Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis. Nature Aging, 4(6), 783–790. https://doi.org/10.1038/s43587-024-00621-3
Richmond-Rakerd, Leah S., Monica T. Iyer, Stephanie D’Souza, Lara Khalifeh, Avshalom Caspi, Terrie E. Moffitt, and Barry J. Milne. “Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis.Nature Aging 4, no. 6 (June 2024): 783–90. https://doi.org/10.1038/s43587-024-00621-3.
Richmond-Rakerd LS, Iyer MT, D’Souza S, Khalifeh L, Caspi A, Moffitt TE, et al. Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis. Nature aging. 2024 Jun;4(6):783–90.
Richmond-Rakerd, Leah S., et al. “Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis.Nature Aging, vol. 4, no. 6, June 2024, pp. 783–90. Epmc, doi:10.1038/s43587-024-00621-3.
Richmond-Rakerd LS, Iyer MT, D’Souza S, Khalifeh L, Caspi A, Moffitt TE, Milne BJ. Associations of hospital-treated infections with subsequent dementia: nationwide 30-year analysis. Nature aging. 2024 Jun;4(6):783–790.

Published In

Nature aging

DOI

EISSN

2662-8465

ISSN

2662-8465

Publication Date

June 2024

Volume

4

Issue

6

Start / End Page

783 / 790

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Registries
  • New Zealand
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Infections
  • Humans
  • Hospitalization