Skip to main content
Journal cover image

Deciphering the TET3 interactome in primary thymic developing T cells.

Publication ,  Journal Article
Theofilatos, D; Ho, T; Waitt, G; Äijö, T; Schiapparelli, LM; Soderblom, EJ; Tsagaratou, A
Published in: iScience
May 17, 2024

Ten-eleven translocation (TET) proteins are DNA dioxygenases that mediate active DNA demethylation. TET3 is the most highly expressed TET protein in thymic developing T cells. TET3, either independently or in cooperation with TET1 or TET2, has been implicated in T cell lineage specification by regulating DNA demethylation. However, TET-deficient mice exhibit complex phenotypes, suggesting that TET3 exerts multifaceted roles, potentially by interacting with other proteins. We performed liquid chromatography with tandem mass spectrometry in primary developing T cells to identify TET3 interacting partners in endogenous, in vivo conditions. We discover TET3 interacting partners. Our data establish that TET3 participates in a plethora of fundamental biological processes, such as transcriptional regulation, RNA polymerase elongation, splicing, DNA repair, and DNA replication. This resource brings in the spotlight emerging functions of TET3 and sets the stage for systematic studies to dissect the precise mechanistic contributions of TET3 in shaping T cell biology.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

iScience

DOI

EISSN

2589-0042

Publication Date

May 17, 2024

Volume

27

Issue

5

Start / End Page

109782

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Theofilatos, D., Ho, T., Waitt, G., Äijö, T., Schiapparelli, L. M., Soderblom, E. J., & Tsagaratou, A. (2024). Deciphering the TET3 interactome in primary thymic developing T cells. IScience, 27(5), 109782. https://doi.org/10.1016/j.isci.2024.109782
Theofilatos, Dimitris, Tricia Ho, Greg Waitt, Tarmo Äijö, Lucio M. Schiapparelli, Erik J. Soderblom, and Ageliki Tsagaratou. “Deciphering the TET3 interactome in primary thymic developing T cells.IScience 27, no. 5 (May 17, 2024): 109782. https://doi.org/10.1016/j.isci.2024.109782.
Theofilatos D, Ho T, Waitt G, Äijö T, Schiapparelli LM, Soderblom EJ, et al. Deciphering the TET3 interactome in primary thymic developing T cells. iScience. 2024 May 17;27(5):109782.
Theofilatos, Dimitris, et al. “Deciphering the TET3 interactome in primary thymic developing T cells.IScience, vol. 27, no. 5, May 2024, p. 109782. Pubmed, doi:10.1016/j.isci.2024.109782.
Theofilatos D, Ho T, Waitt G, Äijö T, Schiapparelli LM, Soderblom EJ, Tsagaratou A. Deciphering the TET3 interactome in primary thymic developing T cells. iScience. 2024 May 17;27(5):109782.
Journal cover image

Published In

iScience

DOI

EISSN

2589-0042

Publication Date

May 17, 2024

Volume

27

Issue

5

Start / End Page

109782

Location

United States