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Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane.

Publication ,  Journal Article
Curtis, BN; Gladfelter, AS
Published in: Cold Spring Harb Perspect Biol
May 2, 2024

This review examines the relationships between membrane chemistry, curvature-sensing proteins, and cellular morphogenesis. Curvature-sensing proteins are often orders of magnitude smaller than the membrane curvatures they localize to. How are nanometer-scale proteins used to sense micrometer-scale membrane features? Here, we trace the journey of curvature-sensing proteins as they engage with lipid membranes through a combination of electrostatic and hydrophobic interactions. We discuss how curvature sensing hinges on membrane features like lipid charge, packing, and the directionality of membrane curvature. Once bound to the membrane, many curvature sensors undergo self-assembly (i.e., they oligomerize or form higher-order assemblies that are key for initiating and regulating cell shape transformations). Central to these discussions are the micrometer-scale curvature-sensing proteins' septins. By discussing recent literature surrounding septin membrane association, assembly, and their many functions in morphogenesis with support from other well-studied curvature sensors, we aim to synthesize possible mechanisms underlining cell shape sensing.

Duke Scholars

Published In

Cold Spring Harb Perspect Biol

DOI

EISSN

1943-0264

Publication Date

May 2, 2024

Location

United States

Related Subject Headings

  • 3105 Genetics
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
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Curtis, B. N., & Gladfelter, A. S. (2024). Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a041528
Curtis, Brandy N., and Amy S. Gladfelter. “Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane.Cold Spring Harb Perspect Biol, May 2, 2024. https://doi.org/10.1101/cshperspect.a041528.
Curtis BN, Gladfelter AS. Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane. Cold Spring Harb Perspect Biol. 2024 May 2;
Curtis, Brandy N., and Amy S. Gladfelter. “Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane.Cold Spring Harb Perspect Biol, May 2024. Pubmed, doi:10.1101/cshperspect.a041528.
Curtis BN, Gladfelter AS. Drivers of Morphogenesis: Curvature Sensor Self-Assembly at the Membrane. Cold Spring Harb Perspect Biol. 2024 May 2;

Published In

Cold Spring Harb Perspect Biol

DOI

EISSN

1943-0264

Publication Date

May 2, 2024

Location

United States

Related Subject Headings

  • 3105 Genetics
  • 3101 Biochemistry and cell biology