Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.
Publication
, Journal Article
Lasrado, N; Collier, A-RY; Hachmann, NP; Miller, J; Rowe, M; Schonberg, ED; Rodrigues, SL; LaPiana, A; Patio, RC; Anand, T; Fisher, J; Guan, R ...
Published in: Vaccine
November 13, 2023
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.
Duke Scholars
Published In
Vaccine
DOI
EISSN
1873-2518
Publication Date
November 13, 2023
Volume
41
Issue
47
Start / End Page
6904 / 6909
Location
Netherlands
Related Subject Headings
- Virology
- SARS-CoV-2
- Immunization, Secondary
- Humans
- COVID-19
- Antibodies, Viral
- Antibodies, Neutralizing
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lasrado, N., Collier, A.-R., Hachmann, N. P., Miller, J., Rowe, M., Schonberg, E. D., … Barouch, D. H. (2023). Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine, 41(47), 6904–6909. https://doi.org/10.1016/j.vaccine.2023.10.051
Lasrado, Ninaad, Ai-Ris Y. Collier, Nicole P. Hachmann, Jessica Miller, Marjorie Rowe, Eleanor D. Schonberg, Stefanie L. Rodrigues, et al. “Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.” Vaccine 41, no. 47 (November 13, 2023): 6904–9. https://doi.org/10.1016/j.vaccine.2023.10.051.
Lasrado N, Collier A-RY, Hachmann NP, Miller J, Rowe M, Schonberg ED, et al. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904–9.
Lasrado, Ninaad, et al. “Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.” Vaccine, vol. 41, no. 47, Nov. 2023, pp. 6904–09. Pubmed, doi:10.1016/j.vaccine.2023.10.051.
Lasrado N, Collier A-RY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023 Nov 13;41(47):6904–6909.
Published In
Vaccine
DOI
EISSN
1873-2518
Publication Date
November 13, 2023
Volume
41
Issue
47
Start / End Page
6904 / 6909
Location
Netherlands
Related Subject Headings
- Virology
- SARS-CoV-2
- Immunization, Secondary
- Humans
- COVID-19
- Antibodies, Viral
- Antibodies, Neutralizing
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences