Visualization of mTOR Pathway Regulated by Traditional Chinese Medicine： A Bibliometric Analysis Based on Multiple Software
Objective：To summarize the research progress of mammalian target of rapamycin（mTOR）pathway regulated by traditional Chinese medicine（TCM） and provide reference for visualization and quantitative analysis of related research based on multiple software linkage. Method： Literature related to TCM regulation of mTOR pathway in Web of Science was taken as the research object. Citespace，VOSviewer，and carrort2 were used for biliometric analysis and visualization of the literature. Result：A total of 245 papers that met the requirements were retrieved，and the visual analysis showed that the papers presented a fluctuating increase year by year after 2010，and numerous research results emerged in 2018. China had the most publications. Institutions with a large number of publications were mainly in Beijing and Shanghai，and most of the regional cooperation was centered in Beijing and Nanjing. According to the research direction and focus，it was found that the intervention of TCM in mTOR pathway in recent years mainly concentrated on the anti-tumor， anti-apoptotic and anti-inflammatory aspects， and TCM interfered with mTOR pathway to regulate cell apoptosis，autophagy，proliferation，and death. AMP-activated protein kinase（AMPK）and phosphatidylinositol 3-kinases（PI3K）/protein kinase B（Akt）/mTOR pathway were the current and future research hotspots. Conclusion：Research on the regulation of mTOR pathway by TCM had a good prospect，and the in-depth study might provide new ideas and guidance for the treatment of cardiovascular diseases，tumor and other major diseases.
