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No evidence for metabolic adaptation during exercise-related energy compensation.

Publication ,  Journal Article
Flanagan, EW; Sanchez-Delgado, G; Martin, CK; Ravussin, E; Pontzer, H; Redman, LM
Published in: iScience
June 2024

The constrained energy model posits that the increased total daily energy expenditure (TDEE) in response to exercise is often less than the energy cost of the exercise prescribed. The mechanisms behind this phenomenon, coined "exercise-related energy compensation" (ExEC), are poorly understood, and it is unknown if ExEC is coupled with metabolic adaptation. Using a randomized controlled 24-week exercise intervention, individuals who demonstrated ExEC were identified. Changes to all components of TDEE and metabolic adaptation were assessed using doubly labeled water over 14 days and room calorimetry over 24-h 48% of individuals exhibited ExEC (-308 ± 158 kcals/day). There were no statistically significant differences in sex, age, or BMI between ExEC and non-ExEC. ExEC was associated with baseline TDEE (r = -0.50, p = 0.006). There were no statistically significant differences in metabolic adaptations for 24 h, sleep, or resting expenditures. These findings reveal that ExEC occurs independent of metabolic adaptation in sedentary components of EE.

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Published In

iScience

DOI

EISSN

2589-0042

ISSN

2589-0042

Publication Date

June 2024

Volume

27

Issue

6

Start / End Page

109842
 

Citation

APA
Chicago
ICMJE
MLA
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Flanagan, E. W., Sanchez-Delgado, G., Martin, C. K., Ravussin, E., Pontzer, H., & Redman, L. M. (2024). No evidence for metabolic adaptation during exercise-related energy compensation. IScience, 27(6), 109842. https://doi.org/10.1016/j.isci.2024.109842
Flanagan, E. W., G. Sanchez-Delgado, C. K. Martin, E. Ravussin, H. Pontzer, and L. M. Redman. “No evidence for metabolic adaptation during exercise-related energy compensation.IScience 27, no. 6 (June 2024): 109842. https://doi.org/10.1016/j.isci.2024.109842.
Flanagan EW, Sanchez-Delgado G, Martin CK, Ravussin E, Pontzer H, Redman LM. No evidence for metabolic adaptation during exercise-related energy compensation. iScience. 2024 Jun;27(6):109842.
Flanagan, E. W., et al. “No evidence for metabolic adaptation during exercise-related energy compensation.IScience, vol. 27, no. 6, June 2024, p. 109842. Epmc, doi:10.1016/j.isci.2024.109842.
Flanagan EW, Sanchez-Delgado G, Martin CK, Ravussin E, Pontzer H, Redman LM. No evidence for metabolic adaptation during exercise-related energy compensation. iScience. 2024 Jun;27(6):109842.
Journal cover image

Published In

iScience

DOI

EISSN

2589-0042

ISSN

2589-0042

Publication Date

June 2024

Volume

27

Issue

6

Start / End Page

109842