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Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens.

Publication ,  Journal Article
Marinelli, T; Kim, HY; Halliday, CL; Garnham, K; Bupha-Intr, O; Dao, A; Morris, AJ; Alastruey-Izquierdo, A; Colombo, A; Rickerts, V; Perfect, J ...
Published in: Med Mycol
June 27, 2024

Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and impact of infections caused by Fusarium spp., Scedosporium spp., and Lomentospora prolificans to inform the first FPPL. PubMed and Web of Sciences databases were searched to identify studies published between January 1, 2011 and February 23, 2021, reporting on mortality, complications and sequelae, antifungal susceptibility, preventability, annual incidence, and trends. Overall, 20, 11, and 9 articles were included for Fusarium spp., Scedosporium spp., and L. prolificans, respectively. Mortality rates were high in those with invasive fusariosis, scedosporiosis, and lomentosporiosis (42.9%-66.7%, 42.4%-46.9%, and 50.0%-71.4%, respectively). Antifungal susceptibility data, based on small isolate numbers, showed high minimum inhibitory concentrations (MIC)/minimum effective concentrations for most currently available antifungal agents. The median/mode MIC for itraconazole and isavuconazole were ≥16 mg/l for all three pathogens. Based on limited data, these fungi are emerging. Invasive fusariosis increased from 0.08 cases/100 000 admissions to 0.22 cases/100 000 admissions over the time periods of 2000-2009 and 2010-2015, respectively, and in lung transplant recipients, Scedosporium spp. and L. prolificans were only detected from 2014 onwards. Global surveillance to better delineate antifungal susceptibility, risk factors, sequelae, and outcomes is required.

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Published In

Med Mycol

DOI

EISSN

1460-2709

Publication Date

June 27, 2024

Volume

62

Issue

6

Location

England

Related Subject Headings

  • World Health Organization
  • Scedosporium
  • Mycoses
  • Microbiology
  • Microbial Sensitivity Tests
  • Invasive Fungal Infections
  • Humans
  • Fusarium
  • Fusariosis
  • Ascomycota
 

Citation

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Marinelli, T., Kim, H. Y., Halliday, C. L., Garnham, K., Bupha-Intr, O., Dao, A., … Morrissey, C. O. (2024). Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens. Med Mycol, 62(6). https://doi.org/10.1093/mmy/myad128
Marinelli, Tina, Hannah Yejin Kim, Catriona L. Halliday, Katherine Garnham, Olivia Bupha-Intr, Aiken Dao, Arthur J. Morris, et al. “Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens.Med Mycol 62, no. 6 (June 27, 2024). https://doi.org/10.1093/mmy/myad128.
Marinelli T, Kim HY, Halliday CL, Garnham K, Bupha-Intr O, Dao A, Morris AJ, Alastruey-Izquierdo A, Colombo A, Rickerts V, Perfect J, Denning DW, Nucci M, Hamers RL, Cassini A, Oladele R, Sorrell TC, Ramon-Pardo P, Fusire T, Chiller TM, Wahyuningsih R, Forastiero A, Al-Nuseirat A, Beyer P, Gigante V, Beardsley J, Sati H, Alffenaar J-W, Morrissey CO. Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens. Med Mycol. 2024 Jun 27;62(6).
Journal cover image

Published In

Med Mycol

DOI

EISSN

1460-2709

Publication Date

June 27, 2024

Volume

62

Issue

6

Location

England

Related Subject Headings

  • World Health Organization
  • Scedosporium
  • Mycoses
  • Microbiology
  • Microbial Sensitivity Tests
  • Invasive Fungal Infections
  • Humans
  • Fusarium
  • Fusariosis
  • Ascomycota