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Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.

Publication ,  Journal Article
Wang, X; Lin, Y; Ge, Y; Craig, E; Liu, X; Miller, RK; Thurston, SW; Brunner, J; Barrett, ES; O'Connor, TG; Rich, DQ; Zhang, JJ
Published in: Environmental pollution (Barking, Essex : 1987)
September 2024

Increased systemic oxidative stress, implicated in adverse pregnancy outcomes for both mothers and fetuses, has been associated with gestational exposure to air pollutants such as polycyclic aromatic hydrocarbons (PAHs), fine particulate matter (PM2.5), and nitrogen dioxide (NO2). However, it is unclear whether exposure to pollutants at levels below the current air quality standards can increase oxidative stress in pregnant women. In a cohort of 305 pregnant persons residing in western New York, we examined the association between exposure to PM2.5, NO2, and PAHs (measured as urinary 1-hydroxypyrene) and urinary biomarkers of oxidative stress (malondialdehyde [MDA] and 8-hydroxy-2'-deoxyguanosine [8-OHdG]) measured in each trimester. After controlling for gestational stage, maternal age, lifestyles, and socioeconomic factors, each interquartile range (IQR) increase in 1-hydroxypyrene concentration (65.8 pg/ml) was associated with a 7.73% (95%CI: 3.18%,12.3%) higher in MDA levels throughout the pregnancy and in the first and second trimester. An IQR increase in PM2.5 concentration (3.20 μg/m3) was associated with increased MDA levels in the first trimester (8.19%, 95%CI: 0.28%,16.1%), but not the 2nd (-7.99%, 95% CI: 13.8%, -2.23%) or 3rd trimester (-2.81%, 95% CI: 10.0%, 4.38%). The average cumulative PM2.5 exposures in the 3-7 days before urine collection were associated with increased 8-OHdG levels during the second trimester, with the largest difference (22.6%; 95% CI: 3.46%, 41.7%) observed in relation to a one IQR increase in PM2.5 concentration in the previous 7 days. In contrast, neither oxidative stress biomarker was associated with NO2 exposure. Observed in pregnant women exposed to low-level air pollution, these findings expanded previously reported associations between systemic oxidative stress and high-level PM2.5 and PAH concentrations. Further, the first and second trimesters may be a susceptible window during pregnancy for oxidative stress responses to air pollution exposure.

Duke Scholars

Published In

Environmental pollution (Barking, Essex : 1987)

DOI

EISSN

1873-6424

ISSN

0269-7491

Publication Date

September 2024

Volume

357

Start / End Page

124463

Related Subject Headings

  • Young Adult
  • Pyrenes
  • Pregnancy
  • Polycyclic Aromatic Hydrocarbons
  • Particulate Matter
  • Oxidative Stress
  • Nitrogen Dioxide
  • New York
  • Maternal Exposure
  • Malondialdehyde
 

Citation

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Wang, X., Lin, Y., Ge, Y., Craig, E., Liu, X., Miller, R. K., … Zhang, J. J. (2024). Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants. Environmental Pollution (Barking, Essex : 1987), 357, 124463. https://doi.org/10.1016/j.envpol.2024.124463
Wang, Xiangtian, Yan Lin, Yihui Ge, Emily Craig, Xiaodong Liu, Richard K. Miller, Sally W. Thurston, et al. “Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.Environmental Pollution (Barking, Essex : 1987) 357 (September 2024): 124463. https://doi.org/10.1016/j.envpol.2024.124463.
Wang X, Lin Y, Ge Y, Craig E, Liu X, Miller RK, et al. Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants. Environmental pollution (Barking, Essex : 1987). 2024 Sep;357:124463.
Wang, Xiangtian, et al. “Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants.Environmental Pollution (Barking, Essex : 1987), vol. 357, Sept. 2024, p. 124463. Epmc, doi:10.1016/j.envpol.2024.124463.
Wang X, Lin Y, Ge Y, Craig E, Liu X, Miller RK, Thurston SW, Brunner J, Barrett ES, O’Connor TG, Rich DQ, Zhang JJ. Systemic oxidative stress levels during the course of pregnancy: Associations with exposure to air pollutants. Environmental pollution (Barking, Essex : 1987). 2024 Sep;357:124463.
Journal cover image

Published In

Environmental pollution (Barking, Essex : 1987)

DOI

EISSN

1873-6424

ISSN

0269-7491

Publication Date

September 2024

Volume

357

Start / End Page

124463

Related Subject Headings

  • Young Adult
  • Pyrenes
  • Pregnancy
  • Polycyclic Aromatic Hydrocarbons
  • Particulate Matter
  • Oxidative Stress
  • Nitrogen Dioxide
  • New York
  • Maternal Exposure
  • Malondialdehyde