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In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.

Publication ,  Journal Article
Zhang, F; Kovalick, K; Raghavendra, A; Soltanian-Zadeh, S; Farsiu, S; Hammer, DX; Liu, Z
Published in: Biomedical optics express
August 2024

Retinal ganglion cells play an important role in human vision, and their degeneration results in glaucoma and other neurodegenerative diseases. Imaging these cells in the living human retina can greatly improve the diagnosis and treatment of glaucoma. However, owing to their translucent soma and tight packing arrangement within the ganglion cell layer (GCL), successful imaging has only been achieved with sophisticated research-grade adaptive optics (AO) systems. For the first time we demonstrate that GCL somas can be resolved and cell morphology can be quantified using non-AO optical coherence tomography (OCT) devices with optimal parameter configuration and post-processing.

Duke Scholars

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

August 2024

Volume

15

Issue

8

Start / End Page

4675 / 4688

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

Citation

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ICMJE
MLA
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Zhang, F., Kovalick, K., Raghavendra, A., Soltanian-Zadeh, S., Farsiu, S., Hammer, D. X., & Liu, Z. (2024). In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical Optics Express, 15(8), 4675–4688. https://doi.org/10.1364/boe.533249
Zhang, Furu, Katherine Kovalick, Achyut Raghavendra, Somayyeh Soltanian-Zadeh, Sina Farsiu, Daniel X. Hammer, and Zhuolin Liu. “In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.Biomedical Optics Express 15, no. 8 (August 2024): 4675–88. https://doi.org/10.1364/boe.533249.
Zhang F, Kovalick K, Raghavendra A, Soltanian-Zadeh S, Farsiu S, Hammer DX, et al. In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical optics express. 2024 Aug;15(8):4675–88.
Zhang, Furu, et al. “In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.Biomedical Optics Express, vol. 15, no. 8, Aug. 2024, pp. 4675–88. Epmc, doi:10.1364/boe.533249.
Zhang F, Kovalick K, Raghavendra A, Soltanian-Zadeh S, Farsiu S, Hammer DX, Liu Z. In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical optics express. 2024 Aug;15(8):4675–4688.
Journal cover image

Published In

Biomedical optics express

DOI

EISSN

2156-7085

ISSN

2156-7085

Publication Date

August 2024

Volume

15

Issue

8

Start / End Page

4675 / 4688

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics