
In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.
Publication
, Journal Article
Zhang, F; Kovalick, K; Raghavendra, A; Soltanian-Zadeh, S; Farsiu, S; Hammer, DX; Liu, Z
Published in: Biomedical optics express
August 2024
Retinal ganglion cells play an important role in human vision, and their degeneration results in glaucoma and other neurodegenerative diseases. Imaging these cells in the living human retina can greatly improve the diagnosis and treatment of glaucoma. However, owing to their translucent soma and tight packing arrangement within the ganglion cell layer (GCL), successful imaging has only been achieved with sophisticated research-grade adaptive optics (AO) systems. For the first time we demonstrate that GCL somas can be resolved and cell morphology can be quantified using non-AO optical coherence tomography (OCT) devices with optimal parameter configuration and post-processing.
Duke Scholars
Published In
Biomedical optics express
DOI
EISSN
2156-7085
ISSN
2156-7085
Publication Date
August 2024
Volume
15
Issue
8
Start / End Page
4675 / 4688
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4003 Biomedical engineering
- 3212 Ophthalmology and optometry
- 0912 Materials Engineering
- 0205 Optical Physics
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, F., Kovalick, K., Raghavendra, A., Soltanian-Zadeh, S., Farsiu, S., Hammer, D. X., & Liu, Z. (2024). In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical Optics Express, 15(8), 4675–4688. https://doi.org/10.1364/boe.533249
Zhang, Furu, Katherine Kovalick, Achyut Raghavendra, Somayyeh Soltanian-Zadeh, Sina Farsiu, Daniel X. Hammer, and Zhuolin Liu. “In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.” Biomedical Optics Express 15, no. 8 (August 2024): 4675–88. https://doi.org/10.1364/boe.533249.
Zhang F, Kovalick K, Raghavendra A, Soltanian-Zadeh S, Farsiu S, Hammer DX, et al. In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical optics express. 2024 Aug;15(8):4675–88.
Zhang, Furu, et al. “In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics.” Biomedical Optics Express, vol. 15, no. 8, Aug. 2024, pp. 4675–88. Epmc, doi:10.1364/boe.533249.
Zhang F, Kovalick K, Raghavendra A, Soltanian-Zadeh S, Farsiu S, Hammer DX, Liu Z. In vivo imaging of human retinal ganglion cells using optical coherence tomography without adaptive optics. Biomedical optics express. 2024 Aug;15(8):4675–4688.

Published In
Biomedical optics express
DOI
EISSN
2156-7085
ISSN
2156-7085
Publication Date
August 2024
Volume
15
Issue
8
Start / End Page
4675 / 4688
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4003 Biomedical engineering
- 3212 Ophthalmology and optometry
- 0912 Materials Engineering
- 0205 Optical Physics