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Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry.

Publication ,  Journal Article
Parsons, RJ; Acharya, P
Published in: Cell
August 8, 2024

The pre-fusion coronavirus HKU1 spike binds host sialoglycans and proteinaceous receptor TMPRSS2 for cell entry. In this issue of Cell, three papers by Fernández et al., McCallum et al., and Wang et al. provide structural information on HKU1 spike interactions with host receptors, providing insights into its multi-step opening.

Duke Scholars

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

August 8, 2024

Volume

187

Issue

16

Start / End Page

4147 / 4149

Location

United States

Related Subject Headings

  • Virus Internalization
  • Spike Glycoprotein, Coronavirus
  • Serine Endopeptidases
  • SARS-CoV-2
  • Humans
  • Developmental Biology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Parsons, R. J., & Acharya, P. (2024). Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry. Cell, 187(16), 4147–4149. https://doi.org/10.1016/j.cell.2024.07.007
Parsons, Ruth J., and Priyamvada Acharya. “Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry.Cell 187, no. 16 (August 8, 2024): 4147–49. https://doi.org/10.1016/j.cell.2024.07.007.
Parsons, Ruth J., and Priyamvada Acharya. “Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry.Cell, vol. 187, no. 16, Aug. 2024, pp. 4147–49. Pubmed, doi:10.1016/j.cell.2024.07.007.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

August 8, 2024

Volume

187

Issue

16

Start / End Page

4147 / 4149

Location

United States

Related Subject Headings

  • Virus Internalization
  • Spike Glycoprotein, Coronavirus
  • Serine Endopeptidases
  • SARS-CoV-2
  • Humans
  • Developmental Biology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences