A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.
Publication
, Journal Article
Yasmin, M; Marshall, SH; Chen, L; Rhoads, DD; Jacobs, MR; Rojas, LJ; Perez, F; Hujer, AM; Hujer, KM; van Duin, D; Fowler, V; Chambers, HF ...
Published in: Antimicrob Agents Chemother
October 8, 2024
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased blaKPC copy numbers. KPC-KP isolates with decreased susceptibility to MV were detected among a collection of isolates predating the availability of MV.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
October 8, 2024
Volume
68
Issue
10
Start / End Page
e0020824
Location
United States
Related Subject Headings
- beta-Lactamases
- Whole Genome Sequencing
- Porins
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Meropenem
- Klebsiella pneumoniae
- Klebsiella Infections
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Yasmin, M., Marshall, S. H., Chen, L., Rhoads, D. D., Jacobs, M. R., Rojas, L. J., … Antibacterial Resistance Leadership Group. (2024). A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother, 68(10), e0020824. https://doi.org/10.1128/aac.00208-24
Yasmin, Mohamad, Steven H. Marshall, Liang Chen, Daniel D. Rhoads, Michael R. Jacobs, Laura J. Rojas, Federico Perez, et al. “A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.” Antimicrob Agents Chemother 68, no. 10 (October 8, 2024): e0020824. https://doi.org/10.1128/aac.00208-24.
Yasmin M, Marshall SH, Chen L, Rhoads DD, Jacobs MR, Rojas LJ, et al. A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0020824.
Yasmin, Mohamad, et al. “A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.” Antimicrob Agents Chemother, vol. 68, no. 10, Oct. 2024, p. e0020824. Pubmed, doi:10.1128/aac.00208-24.
Yasmin M, Marshall SH, Chen L, Rhoads DD, Jacobs MR, Rojas LJ, Perez F, Hujer AM, Hujer KM, van Duin D, Fowler V, Chambers HF, Kreiswirth BN, Bonomo RA, Antibacterial Resistance Leadership Group. A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0020824.
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
October 8, 2024
Volume
68
Issue
10
Start / End Page
e0020824
Location
United States
Related Subject Headings
- beta-Lactamases
- Whole Genome Sequencing
- Porins
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Meropenem
- Klebsiella pneumoniae
- Klebsiella Infections
- Humans